摘要
目的探究桑菊饮加减联合抗感染治疗风热犯肺型肺炎患儿的临床疗效及对其中医证候积分、T淋巴亚群的影响。方法选取2022年8月—2023年8月期间铜陵市中医医院收治的肺炎患儿90例,按简单随机数字表法分为对照组和研究组,每组各45例。对照组常规对症处理基础上采取抗感染治疗,研究组在对照组基础上采取桑菊饮加减方,均治疗7 d。观察比较两组患儿临床疗效、不良反应发生情况,治疗前后中医证候积分、T淋巴亚群指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平、炎症指标[降钙素原(Procalcitonin,PCT)、白细胞计数(White blood cell count,WBC)、C反应蛋白(C-reactive protein,CRP)]水平。结果治疗后研究组临床总有效率93.33%(42/45)明显高于对照组77.78%(35/45),差异有统计学意义(P<0.05)。治疗后两组患儿咽红疼痛、痰黄黏稠、咳痰不爽、发热及纳呆、口渴欲饮、气急喘息、鼻塞流涕积分均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前升高,差异有统计学意义(P<0.05);且研究组T淋巴亚群指标明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿血清PCT、WBC、CRP水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组炎症指标明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,研究组不良反应发生率6.67%(3/45)与对照组4.44%(2/45)比较,差异无统计学意义(P>0.05)。结论常规抗感染基础上联合桑菊饮加减治疗风热犯肺型肺炎,可有效缓解患儿临床症状,调节免疫功能,减轻炎症反应程度,提升疾病整体治疗效果,且具有安全性。
Objective To explore the clinical efficacy of modified Sangjuyin combined with anti-infection treatment and its effect on TCM syndrome scores and T lymphoid subsets in children with wind-heat-induced pulmonary pneumonia.Methods A total of 90 children with pneumonia admitted to Tongling Hospital of Traditional Chinese Medicine from August 2022 to August 2023 were selected and divided into control group and study group by simple random number table method,with 45 cases in each group.On the basis of conventional symptomatic treatment,the control group was treated with anti-infection treatment,and the study group was treated with modified Sangjuyin on the basis of the control group for seven days.The clinical efficacy,occurrence of adverse reactions,TCM syndrome scores,T lymphoid subsets(CD3^(+),CD4^(+),and CD4^(+)/CD8^(+))levels,and inflammatory indicators[procalcitonin(PCT),white blood cell count(WBC),and C-reactive protein(CRP)]levels of the two groups were analyzed before and after treatment.Results After treatment,the total clinical effective rate of the study group was 93.33%(42/45),which was significantly higher than that of the control group 77.78%(35/45),and the difference was statistically significant(P<0.05).The scores of sore throat,yellow and thick phlegm,ungratifying coughing,fever and anorexia,thirst,gasping,nasal congestion,and runny nose in the two groups were lower than before treatment(P<0.05),and the TCM syndrome score of the study group was significantly lower than that of the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the two groups were higher(P<0.05),and the T lymphoid subgroup index of the study group was significantly higher than that of the control group(P<0.05).After treatment,the levels of serum PCT,WBC,and CRP in the two groups were lower(P<0.05),and the inflammation index of the study group was significantly lower than that of the control group(P<0.05).During the treatment period,the incidence of adverse reactions in the study group was 6.67%(3/45)compared with 4.44%(2/45)in the control group,and the difference was not statistically significant(P>0.05).Conclusion Conventional anti-infection combined with modified Sangjuyin for wind-heat-induced pulmonary pneumonia can effectively relieve the clinical symptoms of children,regulate the immune function,reduce the degree of inflammation,and improve the overall treatment effect of disease,and it is safe.
作者
赵丽莹
汪江涛
秦宗富
石锦梅
ZHAO Li-ying;WANG Jiang-tao;QIN Zong-fu;SHI Jin-mei(Department of Pediatrics,Tongling Hospital of Traditional Chinese Medicine,Tongling Anhui 244000)
出处
《世界中西医结合杂志》
2024年第9期1858-1862,共5页
World Journal of Integrated Traditional and Western Medicine
基金
2022年安徽省中医药传承创新科研项目(2022CCYB25)。
关键词
桑菊饮加减
抗感染
风热犯肺
肺炎
T淋巴亚群
Modified Sangjuyin
Anti-Infection
Wind-Heat-Induced Pulmonary Pneumonia
Pneumonia
T Lymphoid Subset
