摘要
目的探讨铒(Er:YAG)钕(Nd:YAG)双波长激光辅助治疗牙周炎的效果,并系统分析其对龈沟液中细胞因子的影响。方法选取厦门医学院附属口腔医院2021年5月至2023年4月诊治的78例慢性牙周炎患者为研究对象,按照随机数表法分为常规组(n=39,采用常规治疗措施)和激光组(n=39,在常规治疗措施的基础上进行Er:YAG和Nd:YAG双波长激光辅助治疗)。比较两组治疗前及治疗后1、3个月的牙周指标,采集并分析两组治疗前后龈沟液中细胞因子水平。结果两组治疗前牙周袋探诊深度(PD)、附着丧失(CAL)、牙龈指数(GI)、牙龈沟出血指数(SBI)比较,差异无统计学意义(P>0.05);与常规组比较,治疗后1、3个月激光组PD、CAL、GI及SBI均降低,差异有统计学意义(P<0.05)。两组治疗前龈沟液中白细胞介素(IL)-8、IL-1β及肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);与常规组比较,治疗后3个月激光组龈沟液中IL-8、IL-1β及TNF-α水平均降低,差异有统计学意义(P<0.05)。结论Er:YAG及Nd:YAG双波长激光辅助治疗慢性牙周炎表现出良好的效果,能够改善牙周指标并有效调节龈沟液中细胞因子水平,减轻炎症的程度,促进牙周组织修复。
Objective To investigate the therapeutic effect of Er:YAG and Nd:YAG dual-wavelength laserassisted treatment of periodontitis and its effect on cytokines in gingival crevicular fluid.Methods A total of 78 patients with chronic periodontitis treated in the Stomatological Hospital of Xiamen Medical College from May 2021 to April 2023 were selected as the study subjects.They were divided into a conventional group(n=39,received conventional treatment measures)and a laser group(n=39,supplemented with the combined adjuvant treatment of Er:YAG and Nd:YAG dual-wavelength lasers on top of the conventional treatment measures)using a random number table method.Compare the periodontal indicators of two groups before and after treatment for 1 and 3 months,and collect and analyze the cytokine levels in gingival crevicular fluid of the two groups before and after treatment.Results The comparison of periodontal pocket probing depth(PD),clinical attachment loss(CAL),gingival index(GI)and sulcus bleeding index(SBI)between the two groups of patients before treatment,the difference was not statistically significant(P>0.05),compared with the conventional group,after the first month and the third month after treatment,the laser group had low PD,CAL,GI and SBI,and the difference was statistically significant(P<0.05).The comparison of interleukin(IL)-8,IL-1βand tumor necrosis factorα(TNF-α)levels between the two groups of patients before treatment,the difference was not statistically significant(P>0.05),Compared with the conventional group,after the third month of treatment,the laser group had low levels of IL-8,IL-1βand TNF-α,and the difference was statistically significant(P<0.05).Conclusion Er:YAG and Nd:YAG dual-wavelength lasers show good effects in the treatment of chronic periodontitis,which can improve periodontal indexes and effectively regulate the level of cytokines in gingival crevicular fluid,reduce the degree of inflammation and promote periodontal tissue repair.
作者
郭秀宏
刘联哲
林丹萍
GUO Xiuhong;LIU Lianzhe;LIN Danping(Department of Periodontology,Stomatological Hospital of Xiamen Medical College,Fujian,Xiamen 361000,China)
出处
《中国医药科学》
2024年第18期163-166,共4页
China Medicine And Pharmacy
基金
福建省中青年教师教育科研项目(JAT190828)。
关键词
慢性牙周炎
铒激光
钕激光
临床效果
细胞因子
Chronic periodontitis
Er:YAG laser
Nd:YAG laser
Clinical ef fects
Cytokines
