摘要
目的探讨射线防护喷剂外喷治疗对乳腺癌患者术后放疗引起的放射性皮肤损伤的效果。方法选取2021年1月至2024年1月在苏州市第九人民医院102例进行直线加速器放疗治疗后产生放射性皮肤损伤的早期乳腺癌术后患者作为研究对象,采用随机数字表法将患者分为对照组与治疗组,每组51例。对照组患者接受常规复方维生素B_(12)溶液外喷治疗,治疗组患者接受射线防护喷剂(抗辐喷)外喷治疗。比较2组患者治疗效果,以及治疗前后放射性皮肤损伤评估量表(RISRAS)和Karnofsky功能状态(KPS)评分;采用酶联免疫吸附法检测并比较2组患者治疗前后血清炎性因子[血清表皮细胞因子(EGF)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]水平。结果治疗组痊愈时间为(17.66±2.51)d,短于对照组[(24.30±2.69)d],差异有统计学意义(P<0.05)。治疗后,治疗组RISRAS评分为(4.50±1.20)分,低于对照组[(6.15±1.15)分],差异有统计学意义(P<0.05);治疗组KPS评分为(86.01±3.22)分,高于对照组[(81.34±4.35)分],差异有统计学意义(P<0.05)。治疗后,治疗组血清TNF-α、IL-6水平分别为(321.64±37.60)pg/ml和(2.11±0.62)ng/L,均低于对照组[(360.11±32.11)pg/ml和(2.70±0.74)ng/L],治疗组血清EGF水平为(1445.30±127.94)pg/ml,高于对照组[(1257.84±130.57)pg/ml],差异均有统计学意义(均P<0.05)。结论射线防护喷剂外喷治疗能显著改善乳腺癌患者术后放疗引起的放射性皮肤损伤,并提高患者的整体生活质量,降低血清炎性因子水平,推荐作为乳腺癌术后放疗的辅助治疗方式。
Objective To investigate the effectiveness of topical application of radiation protection spray in preventing radiation-induced skin injury in breast cancer patients undergoing postoperative radiotherapy.Methods From January 2021 to January 2024,102 early-stage breast cancer patients who developed radiation-induced skin damage after undergoing postoperative linear accelerator radiotherapy were selected as research subjects at the Ninth People's Hospital in Suzhou.The patients were randomly divided into a control group and a treatment group using a random number table method,with 51 patients in each group.The control group received routine external application of compound vitamin B_(12) solution,while the treatment group received external application of radiation protection spray(Antifu Spray).The treatment efficacy of the two groups was compared,as well as Radiation-Induced Skin Reaction Assessment Scale(RISRAS)and Karnofsky Performance Status(KPS)scores before and after treatment.Enzyme-linked immunosorbent assay(ELISA)was used to detect and compare serum inflammatory factors[epidermal growth factor(EGF),interleukin-6(IL-6),and tumor necrosis factor-alpha(TNF-α)]levels before and after treatment.Results The recovery time in the treatment group was(17.66±2.51)days,shorter than in the control group which was(24.30±2.69)days,with statistically significant differences(P<0.05).After treatment,the RISRAS score in the treatment group was(4.50±1.20),which was lower than(6.15±1.15)in the control group,showing a statistically significant difference(P<0.05).The KPS score in the treatment group was(86.01±3.22),which was higher than(81.34±4.35)in the control group,with a statistically significant difference(P<0.05).After treatment,serum TNF-αand IL-6 levels in the treatment group were(321.64±37.60)pg/ml and(2.11±0.62)ng/L,respectively,lower than in the control group[(360.11±32.11)pg/ml and(2.70±0.74)ng/L].Serum EGF levels in the treatment group were(1445.30±127.94)pg/ml,higher than in the control group[(1257.84±130.57)pg/ml],with statistically significant differences(all P<0.05).Conclusions External application of radiation protection spray significantly improves radiation-induced skin injury in breast cancer patients undergoing postoperative radiotherapy,enhances overall quality of life,and reduces serum inflammatory factor levels.It is recommended as an adjunctive treatment for breast cancer patients receiving postoperative radiotherapy.
作者
洪燕
张英
张晓亭
Hong Yan;Zhang Ying;Zhang Xiaoting(Radiation Oncology Department,the Ninth People's Hospital of Suzhou,Suzhou 215200,China;Emergency Department,the Ninth People's Hospital of Suzhou,Suzhou 215200,China;Oncology Department,the Ninth People's Hospital of Suzhou,Suzhou 215200,China)
出处
《中国肿瘤临床与康复》
2024年第7期443-449,共7页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
乳腺肿瘤
放射治疗
射线防护喷剂
放射性皮肤损伤
炎性因子
Breast neoplasm
Postoperative radiotherapy
Anti-radiation spray
Radiation-induced skin injury
Inflammatory markers
