摘要
目的:研究分析归脾汤加减联合免疫化学药物治疗气血亏虚型非小细胞肺癌(NSCLC)疗效。方法:选取2021年1月—2023年12月井冈山大学附属医院和峡江县人民医院收治的60例中医辨证为气血亏虚型的非小细胞肺癌患者作为本次研究对象,根据不同治疗方案进行分组,即对照组与观察组,各30例。2组患者均接受免疫化学药物、护胃、营养支持、镇痛等常规对症治疗。对照组实施免疫化学药物治疗,采用含替雷利珠单抗免疫化学药物治疗方案,治疗3个疗程,至疾病进展,或有不耐受毒性。观察组采用归脾汤加减联合免疫化学药物,治疗3个疗程。比较2组患者临床治疗效果、气血亏虚型中医证候积分、功能状态评分、生存质量评分及不良反应发生情况差异。结果:经不同用药方案治疗后,观察组临床治疗总有效率高于对照(P<0.05);观察组气血亏虚型中医证候积分低于对照组(P<0.05);观察组生活质量评分各条目得分均优于对照组(P<0.05);观察组肿瘤病人功能状态评分低于对照组(P<0.05);与对照组相比,观察组患者的周围神经损伤、免疫性肺炎、骨髓抑制、胃肠道反应及肝肾功能异常等不良反应发生率显著降低,差异具有统计学意义(P<0.05)。结论:采用归脾汤加减联合免疫化学药物治疗气血亏虚型非小细胞肺癌疗效显著,不仅能够有效缓解患者气血亏虚的症状,还能够降低西医治疗过程中的不良反应发生率,显著提升患者的生活质量。
Objective:To study and analyze the therapeutic effect of modified Guipi Decoction combined with immunochemical drugs in the treatment of non-small cell lung cancer(NSCLC)with Qi-blood deficiency.Methods:From January 2021 to December 2023,60 cases of nonsmall cell lung cancer with syndrome differentiation of Qi-blood deficiency in the affiliated hospital of Jinggangshan university and Xiajiang County people's hospital were selected as the subjects of this study.According to different treatment schemes,they were divided into control group and observation group,with 30 patients in each group.Both groups received routine symptomatic treatment such as immunochemical drugs,gastric care,nutritional support and analgesia.Control group:immunochemical therapy was performed,and the immunochemical therapy regimen containing tirellizumab was used for 3 courses until the disease progressed or had intolerance toxicity.Observation group:Guipi Decoction combined with immunochemical drugs was treated for 3 courses.The clinical therapeutic effect,TCM syndrome score of Qiblood deficiency type,functional status score,quality of life score and adverse reactions were compared between the two groups.Results:The total effective rate of observation group was higher than that of control group(P<0.05).The TCM syndrome score of Qi-blood deficiency in the observation group was lower than that in the control group(P<0.05).The quality of life scores of the observation group were better than those of the control group(P<0.05).The functional status score in observation group was lower than that in control group(P<0.05).Compared with the control group,the incidence of peripheral nerve injury,immune pneumonia,bone marrow suppression,gastrointestinal reaction and abnormal liver and kidney function in observation group was significantly reduced,with statistical significance(P<0.05).Conclusion:Modified Guipi Decoction combined with immunochemical drugs in the treatment of non-small cell lung cancer with Qi-blood deficiency has significant curative effect,which can not only effectively relieve the TCM syndrome of Qi-blood deficiency in patients,but also reduce the incidence of adverse reactions during Western treatment,and significantly improve the quality of life of patients.It has high promotion value.
作者
廖明
谢志明
邓娟华
谢魁
刘彬
邹国明
LIAO Ming;XIE Zhiming;DENG Juanhua;XIE Kui;LIU Bin;ZOU Guoming(Xiajiang County People's Hospital of Jiangxi Province,Xiajiang 331409,China;The Affiliated Hospital of Jinggangshan University,Ji'an 343600,China;Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《江西中医药大学学报》
2024年第5期39-42,46,共5页
Journal of Jiangxi University of Chinese Medicine
基金
江西省教育厅科学技术研究项目(GJJ2201628)。
关键词
归脾汤加减
免疫化学药物
气血亏虚型
非小细胞肺癌
疗效观察
Modified Guipi Decoction
Immunochemical Drug
Qi-blood Deficiency Type
Non-small Cell Lung Cancer
Curative Effect Observation
