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自噬在酒精性肝病中作用及机制研究进展

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摘要 酒精性肝病(ALD)发病机制复杂,目前尚无有效治疗药物。自噬是一种保守的细胞内分解代谢的过程,在肝脏中发挥重要作用。本文从自噬的角度综述了酒精对于自噬的调控机制以及在酒精性肝病中的作用进展,并探讨了基于自噬的ALD的潜在治疗药物。
出处 《肝脏》 2024年第8期891-896,共6页 Chinese Hepatology
基金 陕西省自然科学基础研究计划(2024JC-ZDXM-50,2022JM-569)。
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  • 1Kim JH,Kim JE,Kim HJ,Roh GS,Yoo JM,Kang SS,Cho YY,Cho GJ,Choi WS.Ethanol decreases the expression of mitochondrial cytochrome c oxidase mRNA in the rat.Neurosci Lett 2001; 305:107-110
  • 2Bailey SM,Cunningham CC.Contribution of mitochondria to oxidative stress associated with alcoholic liver disease.Free Radic Biol Med 2002; 32:11-16
  • 3Venkatraman A,Shiva S,Davis AJ,Bailey SM,Brookes PS,Darley-Usmar VM.Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide.Hepatology 2003; 38:141-147
  • 4Bailey SM,Pietsch EC,Cunningham CC.Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III.Free Radic Biol Med 1999; 27:891-900
  • 5Junge J,Horn T,Christoffersen P.Megamitochondria as a diagnostic marker for alcohol induced centrilobular and periportal fibrosis in the liver.Virchows Arch A Pathol Anat Histopathol 1987; 410:553-558
  • 6Rodriguez-Enriquez S,Kim I,Currin RT,Lemasters JJ.Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes.Autophagy 2006; 2:39-46
  • 7Kim I,Rodriguez-Enriquez S,Lemasters JJ.Selective degradation of mitochondria by mitophagy.Arch Biochem Biophys 2007; 462:245-253
  • 8Elmore SP,Qian T,Grissom SF,Lemasters JJ.The mitochondrial permeability transition initiates autophagy in rat hepatocytes.FASEB J 2001; 15:2286-2287
  • 9Masaki R,Yamamoto A,Tashiro Y.Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver.J Cell Biol 1987; 104:1207-1215
  • 10Luiken JJ,van den Berg M,Heikoop JC,Meijer AJ.Autophagic degradation of peroxisomes in isolated rat hepatocytes.FEBS Lett 1992; 304:93-97

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