摘要
背景:铁死亡是一种铁依赖性脂质过氧化调控的程序性细胞死亡方式,与缺血性脑损伤的发生、发展及转归密切相关。近年来,随着对铁死亡研究的不断深入,发现中药复方、中药单体可通过减轻铁超载、减少活性氧产生、调控脂质合成等方式调节铁死亡,减轻脑缺血损伤,促进神经功能恢复。目的:探讨铁死亡与缺血性脑损伤的关系及中药调控铁死亡治疗缺血性脑损伤的作用机制。方法:以“铁死亡,缺血性中风,脑损伤,活性氧,脂质代谢,中药复方,萜类,黄酮,酚类,生物碱,苯酞类等”为中文检索词,以“Iron death,ischemic stroke,brain injury,reactive oxygen species,lipid metabolism,traditional Chinese medicine formulas,terpenes,flavonoids,phenols,alkaloids,phthalides,etc”为英文检索词,检索2018年1月至2024年5月中国知网和PubMed数据库中有关铁死亡与缺血性脑损伤及中药调控机制的文献,排除与文章相关性不高及重复、过时的文献。共检索出1526篇相关文献,最终纳入87篇文献进行综述。结果与结论:大量实验研究证实,铁死亡在缺血性脑损伤中具有重要作用,中医方药可通过多种方式调节铁死亡,如三七总皂苷可调节铁代谢,抑制脂质过氧化;香芹酚通过增加谷胱甘肽过氧化物酶4表达,抑制神经元铁死亡;中药复方和单体有效成分可调控铁死亡相关通路——谷胱甘肽/谷胱甘肽过氧化物酶4(GPX4)、核因子E2相关因子2(Nrf2)/血红素加氧酶1(HO-1)、铁死亡抑制蛋白1(FSP1)/CoQ10及鸟苷三磷酸环水解酶1(GCH1)/四氢生物喋呤(BH4)等,减少神经元损伤和死亡,发挥脑保护作用。
BACKGROUND:Ferroptosis is a programmed cell death mode regulated by iron dependent lipid peroxidation,closely related to the occurrence,development,and outcome of ischemic brain injury.With the continuous deepening of research on ferroptosis in recent years,it has been found that Chinese herbal compounds and monomers can regulate ferroptosis by reducing iron overload,reducing the production of reactive oxygen species,and regulating lipid synthesis,to alleviate cerebral ischemic injury and promote neurological function recovery.OBJECTIVE:To explore the relationship between ferroptosis and ischemic brain injury,and the mechanism by which traditional Chinese medicine regulates ferroptosis in the treatment of ischemic brain injury.METHODS:Literature on ferroptosis and ischemic brain injury and the regulatory mechanism of traditional Chinese medicine published from January 2018 to May 2024 was searched in CNKI and PubMed databases.The search terms were“iron death,ischemic stroke,brain injury,reactive oxygen species,lipid metabolism,traditional Chinese medicine formulas,terpenes,flavonoids,phenols,alkaloids,phthalides”in Chinese and English,respectively.Irrelevant,duplicated or outdated literature was excluded.A total of 1526 relevant literature were retrieved,and 87 articles were ultimately included.RESULTS AND CONCLUSION:Numerous experimental studies have confirmed that ferroptosis plays an important role in ischemic brain injury.Chinese medicine prescriptions can regulate ferroptosis through various approaches,for examples:total saponins of Panax notoginseng can regulate iron metabolism and inhibit lipid peroxidation;carvacrol inhibits neuronal ferroptosis by increasing glutathione peroxidase 4 expression;Chinese herbal compounds and monomeric active ingredients can regulate ferroptosis-related pathways,such as glutathione/glutathione peroxidase 4(GPX4),nuclear factor E2-related factor 2(Nrf2)/hemoglobin oxygenase 1(HO-1),ferric death inhibitory protein 1(FSP1)/CoQ10 and guanosine triphosphate cyclohydrolase 1(GCH1)/tetrahydrobiopterin(BH4),to reduce neuronal damage and death,and exert neuroprotective effects.
作者
周盼盼
杨潼
王姝瑞
崔应麟
Zhou Panpan;Yang Tong;Wang Shurui;Cui Yinglin(The Second Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450002,Henan Province,China;Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,Henan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2025年第17期3675-3683,共9页
Chinese Journal of Tissue Engineering Research
基金
河南省中医药科学研究专项课题(2023ZY1007),项目负责人:崔应麟
具身视角下河南省中医药健康旅游发展现状及对策研究(TCM2022018),项目负责人:杨潼
国家中医药管理局2022年第二届全国名中医传承工作室建设项目(国中医药办人教函[2022]245号),项目负责人:崔应麟。
关键词
铁死亡
缺血性脑损伤
信号通路
中医药
作用机制
ferroptosis
ischemic brain injury
signaling pathway
traditional Chinese medicine
mechanism of action
