摘要
探讨肠道菌群干预联合左乙拉西坦、吡仑帕奈治疗对成人局灶性癫痫患者的临床治疗效果的影响;将局灶性癫痫患者随机分为观察组(常规治疗+肠道菌群干预)与对照组(常规治疗),各78例。治疗前,两组各项指标无显著差异(P>0.05);治疗后,观察组患者癫痫发作频率降低,无发作率(92.31%)、总有效率(80.77%)提高(P<0.05),生活质量与睡眠质量改善(P<0.05);认为肠道菌群干预联合常规治疗能提升成人局灶性癫痫患者的疗效,为局灶性癫痫治疗提供了新证据和思路。
The paper explores the impact of gut microbiota intervention combined with levetiracetam and perampanel on the clinical therapeutic efficacy in adult patients with focal epilepsy.Patients with focal epilepsy were randomly divided into an observation group(conventional therapy+gut microbiota intervention)and a control group(conventional therapy),with 78 cases in each group.Before treatment,there were no significant differences in various indicators between the two groups(P>0.05);after treatment,patients in the observation group exhibited a reduction in seizure frequency,with an increase in the rate of seizure-free patients(92.31%)and overall effective rate(80.77%)(P<0.05),as well as improvements in quality of life and sleep quality(P<0.05).It is suggested that gut microbiota intervention combined with conventional therapy enhance the therapeutic efficacy for adult patients with focal epilepsy,providing new evidence and insights for the treatment of focal epilepsy.
作者
何俊伟
薛丽虹
张一攀
HE Junwei;XUE Lihong;ZHANG Yipan(Department of Neurology,The Affiliated Hospital of Putian University,Putian Fujian 351100,China)
出处
《莆田学院学报》
2024年第5期52-58,共7页
Journal of putian University
基金
福建省教育厅中青年教师教育科研项目(JAT210419)。
关键词
肠道菌群
局灶性癫痫
癫痫患者生活质量量表-89
匹兹堡睡眠质量指数
酶联免疫吸附试验
视频脑电图
gut microbiota
focal epilepsy
quality of life in epilepsy inventory-89(QOLIE-89)
Pittsburgh sleep quality index(PSQI)
enzyme-linked immunosorbent assay
video-electroencephalography
