摘要
目前,肾脏移植术后并发肿瘤已是大多数国家肾脏移植受者的第2大死亡原因,直接关系受者的长期存活及生存质量,需要临床高度关注。肾脏移植术后并发肿瘤的发生风险是与之年龄和性别匹配的普通人群的2~3倍,主要是由病毒和免疫相关因素导致。一旦肿瘤进展,通常预后很差,特别是黑色素瘤、肾细胞癌和移植后淋巴增生性疾病。为进一步规范肾脏移植术后非泌尿系统肿瘤的诊断与治疗,中华医学会器官移植学分会发起制订《中国肾脏移植受者非泌尿系统肿瘤诊疗指南(2023版)》,并组织器官移植学专家,依据现有临床指南、系统评价、病例研究、专家共识等资料,总结近年来国内外在肾脏移植受者术后非泌尿系统肿瘤诊治方面的新进展,以期为肾脏移植术后非泌尿系统肿瘤的诊疗提供参考。
Post-transplant malignancies have become the second leading cause of mortality among kidney transplant(KT)recipients in many countries,significantly affecting long-term survival and quality-of-life.This issue demands heightened clinical awareness.The risk of developing tumors after KT is approximately two to three folds higher than that of general population matched by age and gender,primarily due to viral and immune-related factors.Once tumors progress,the prognosis is often poor,particularly in cases of melanoma,kidney cell carcinoma and post-transplant lymphoproliferative disorders.To further standardize the managements of non-urinary tract tumors after KT,Branch of Organ Transplantation,Chinese Medical Association initiated the drafting of the Chinese guideline for clinical diagnosis and treatment of non-urinary tract tumors in kidney transplant recipients(2023 edition).Compiled by senior experts in organ transplantation,this guideline was based upon existing clinical guidelines,systematic reviews,case studies and expert consensus.It summarized the latest advances in the diagnosis and treatment of non-urinary tract tumors in KT recipients,both domestically and internationally,with an objective goal of providing valuable references for managing non-urinary tract tumors in KT recipients.
作者
中华医学会器官移植学分会
田野
Branch of Organ Transplantation,Chinese Medical Association;Tian Ye(不详;Department of Urology,Beijing Friendship Hospital,Capital Medical University,Institute of Urology,Beijing Municipal Health Commission,Beijing 100050,china)
出处
《中华器官移植杂志》
CAS
2024年第10期689-698,共10页
Chinese Journal of Organ Transplantation
基金
国家自然科学基金(82000717)
北京市自然科学基金(7192043、7194250)
北京市医院管理中心"青苗计划"计划项目(QML20190106)
北京市医师科学家培训项目(BJPSTP-2024-30)。
关键词
肾脏移植
肿瘤
诊断
治疗
指南
Kidney transplantation
Tumors
Diagnosis
Treatment
Guideline
