摘要
目的探讨宫颈环形电切手术(loop electrosurgical excision procedure,LEEP)联合重组人干扰素α-2b(interferon-α-2b,IFN-α-2b)凝胶治疗宫颈高危型人乳头状瘤病毒(high risk human papillomavirus,HR-HPV)感染所致宫颈低级别鳞状上皮内病变(low grade squamous intraepithelial lesion,LSIL)的效果。方法收集2019年1月—2023年12月定西市临洮县妇幼保健院收治的HR-HPV感染所致的LSIL患者160例,随机分为对照组和联合组各80例。对照组采用LEEP进行治疗;观察组在对照组基础上加用IFN-α-2b凝胶进行局部治疗。比较两组治疗后炎症因子改善情况和HR-HPV感染转归情况。结果治疗3个月后,联合组TNF-α、IL-6、IL-8、IL-10水平低于对照组,而IL-17、IL-23水平高于对照组,差异有统计学意义(P<0.05)。联合组治疗3个月后、6个月后、9个月后的HR-HPV转阴率高于对照组,而治疗12个月后的HR-HPV复发率低于对照组,差异有统计学意义(P<0.05)。结论LEEP联合IFN-α-2b凝胶可以进一步改善HR-HPV感染所致LSIL患者的炎症状态,并且进一步提高感染转阴率和降低复发率。
Objective To explore the effect of loop electrosurgical excision procedure(LEEP)combined with recombinant human interferon-α-2b(IFN-α-2b)gel on low grade squamous intraepithelial lesions(LSIL)caused by high-risk human papillomavirus(HR-HPV)infection of the cervix.Methods One hundred and sixty patients with LSIL caused by HR-HPV infection admitted to Maternal and Child Health Hospital of Lintao in Dingxi from January 2019 to December 2023 were randomly divided into a control group and a combination group,with 80 cases in each group.The control group was treated with LEEP,while the observation group added IFN-α-2b gel on the basis of the control group for local treatment.The improvement of inflammatory factors and the outcome of HR-HPV infection between two groups after treatment were compared.Results After 3 months of treatment,the levels of TNF-α,IL-6,IL-8 and IL-10 in the combined group were lower than those in the control group,while the levels of IL-17 and IL-23 in the combined group were significantly higher than those in the control group(P<0.05).The negative rate of HR-HPV in the combined group was higher than that in the control group after 3 months,6 months and 9 months of treatment,while the recurrence rate of HR-HPV was lower than that of the control group after 12 months of treatment(P<0.05).Conclusion The combination of LEEP and IFN-α-2b gel could further improve the inflammatory status of LSIL patients caused by HR-HPV infection,and further increase the infection conversion rate and reduce the recurrence rate.
作者
王倩
WANG Qian(Maternal and Child Health Hospital of Lintao County,Dingxi 730500,Gansu Province,China)
出处
《中国实用乡村医生杂志》
2024年第8期65-67,71,共4页
Chinese Practical Journal of Rural Doctor
关键词
高危型人乳头瘤病毒
低级别鳞状上皮内病变
宫颈环形电切手术
干扰素
High Risk Human Papillomavirus
Low Grade Squamous Intraepithelial Lesions
Loop Electrosurgical Excision Procedure
Interferon
