摘要
目的探究妊娠期高血压疾病(HDP)患者孕晚期血脂代谢异常状况及对妊娠结局的影响。方法收集孕晚期HDP患者(观察组)、孕中期HDP患者(对照1组)和孕晚期体检正常孕妇(对照2组)各146例作为研究对象。比较观察组与对照2组、对照1组的甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总胆固醇(TC)异常率;比较观察组血脂代谢正常者与异常者的血脂水平、年龄、孕期体质量增长情况、HDP病情和妊娠结局。结果观察组的TG、HDL、LDL、TC异常率和血脂代谢总异常率均明显高于对照2组(P<0.05)。观察组的妊娠期高血压发生率低于对照1组,子痫前期、子痫发生率、TG、HDL异常率和血脂代谢总异常率均明显高于对照1组(P<0.05)。观察组血脂代谢异常者的TG、LDL、TC水平及高龄、孕期体质量增幅偏大者占比均明显高于血脂代谢正常者,HDL水平低于血脂代谢正常者,胎膜早破、胎儿窘迫、剖宫产、早产和低体重儿发生率均明显高于血脂代谢正常者(P<0.05);两类患者的HDP病情有显著差异(P<0.05)。结论孕晚期HDP患者血脂代谢存在明显异常,可能与其年龄、孕期体质量过度增长等有关,孕晚期HDP伴发血脂代谢异常会增加不良妊娠结局发生风险。
Objective To explore the abnormal blood lipid metabolism in patients with hypertensive disorder of pregnancy(HDP)in late pregnancy and its influence on pregnancy outcome.Methods A total of 146 patients with HDP in late pregnancy(observation group),146 patients with HDP in the second trimester(control group 1)and 146 pregnant women with normal physical examination in late pregnancy(control group 2)were collected as the research objects.The abnormal rates of triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL)and total cholesterol(TC)were compared between the observation group and the control group 2,the control group 1.The blood lipid level,age,weight gain during pregnancy,HDP condition and pregnancy outcome were compared between the patients with normal blood lipid metabolism and those with abnormal blood lipid metabolism in the observation group.Results The abnormal rates of TG,HDL,LDL,TC and total abnormal rate of lipid metabolism in the observation group were significantly higher than those in the control group 2(P<0.05).The incidence of gestational hypertension was lower than that of the control group 1,and the incidence of preeclampsia and eclampsia,the abnormal rate of TG,HDL and the total abnormal rate of blood lipid metabolism in the observation group were significantly higher than those of the control group 1(P<0.05).The levels of TG,LDL,TC,the proportions of patients with advanced age and large weight gain during pregnancy in the observation group with abnormal blood lipid metabolism were significantly higher than those with normal blood lipid metabolism,and the HDL level was lower than that with normal blood lipid metabolism,and the incidences of premature rupture of membranes,fetal distress,cesarean section,premature delivery and low birth weight infants were significantly higher than those with normal blood lipid metabolism(P<0.05);there was a significant difference in HDP condition between the two types of patients(P<0.05).Conclusion There are obvious abnormalities in blood lipid metabolism in patients with HDP in late pregnancy,which may be related to their age and excessive weight gain during pregnancy.Abnormal blood lipid metabolism in late pregnancy will increase the risk of adverse pregnancy outcomes.
作者
邹雅芝
罗鑫
ZOU Yazhi;LUO Xin(Gynecology and Obstetrics Department,Xi'an People's Hospital/Xi'an Fourth Hospital,Xi'an 710004,China)
出处
《临床医学研究与实践》
2024年第30期69-72,共4页
Clinical Research and Practice
关键词
孕晚期
妊娠期高血压疾病
血脂代谢
妊娠结局
late pregnancy
hypertensive disorders of pregnancy
blood lipid metabolism
pregnancy outcome
