摘要
目的探讨右美托咪定(DEX)在全髋关节置换术(THA)后自控镇痛中的应用效果。方法按随机数字表法将2021年2月~2023年1月于我院行THA治疗的86例老年患者分为两组,各43例。所有患者均行THA治疗,术后对照组采用布托啡诺自控静脉镇痛(PCIA),观察组采用DEX复合布托啡诺PCIA。比较两组疼痛程度、镇静效果、生物化学指标及不良反应。结果观察组术后6 h、12 h时的视觉模拟评分法(VAS)及Ramsay评分均低于对照组,两组术后P物质(SP)、5-羟色胺(5-HT)水平均高于术前,且观察组低于对照组,观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论DEX复合布托啡诺用于老年THA术后PCIA中安全有效,能够提供良好的镇痛、镇静效果,减少SP及5-HT的释放,且不良反应少。
OBJECTIVE To investigate the efficacy of dexmedetomidine(DEX)in controlled analgesia after total hip arthroplasty(THA).METHODS A total of 86 elderly patients treated with THA in our hospital from February 2021 to January 2023 were divided into two groups with 43 cases in each group by random number table method.All patients were treated with THA,the control group was treated with butorphanol controlled intravenous analgesia(PCIA),and the observation group was treated with DEX combined with Butorphanol PCIA.Pain degree,sedation effect,biochemical indexes and adverse reactions were compared between the two groups.RESULTS Visual analogue scale(VAS)and Ramsay score at 6 h and 12 h were lower in the observation group than in the control group.Post-operation,the levels of Substance P(SP)and 5-hydroxytryptamine(5-HT)were elevated in both groups.Notably,the group observed showed a reduction compared to the control group,with a lower frequency of adverse reactions in the observation group as opposed to the control group,a difference statistically significant(P<0.05).CONCLUSION The combination of DEX and butorphanol is secure and efficient for treating PCIA in older patients post-THA.It can provide good analgesic and sedative effects,reduce the release of SP and 5-HT,and have few adverse reactions.
作者
黄虹霞
邓志成
郑增芳
HUANG Hong-xia;DENG Zhi-cheng;ZHENG Zeng-fang(Guangfeng District People′s Hospital,Shangrao 334600,China)
出处
《海峡药学》
2024年第10期93-95,共3页
Strait Pharmaceutical Journal
关键词
老年全髋关节置换术
右美托咪定
布托啡诺
术后静脉自控镇痛
镇痛镇静效果
Total hip replacement in the elderly
Dexmedetomidine
Butorphanol
Postoperative intravenous controlled analgesia
Analgesic and sedative effect
