摘要
目的探究雷公藤甲素联合介入栓塞化疗对宫颈癌患者性激素水平及远期生存情况的影响。方法选取2020年6月至2022年6月就诊的62例宫颈癌患者,随机分为常规组和联合组,每组31例。所有患者均给予常规对症治疗及介入栓塞化疗,联合组则在此基础上加用雷公藤甲素。观测并比较2组的近期缓解率、不同时间点性激素水平、不良反应及远期随访结果。结果联合组治疗后的总缓解率为83.87%,显著大于常规组的总缓解率58.06%(P<0.05)。化疗半年后,2组患者雌激素(E2)水平均显著下降,且联合组低于常规组(P<0.05),联合组促卵泡生成素(FSH)、促黄体生成素(LH)水平均显著下降,常规组FSH和LH水平均显著上升(P<0.05);化疗结束半年后,联合组FSH、E2和LH水平均恢复至化疗前水平,常规组的FSH和LH水平均显著下降,E2水平显著升高(P<0.05),且2组比较,差异有统计学意义(P<0.05)。联合组发生胃肠道反应的比例显著低于常规组(P<0.05)。联合组的3年生存率和局部复发率分别为67.74%和9.68%,常规组的3年生存率和局部复发率分别为54.84%和25.81%,2组比较,差异无统计学意义(P>0.05);联合组的远处转移率为3.23%,显著小于常规组的远处转移率19.35%(P<0.05)。结论雷公藤甲素联合介入栓塞化疗对宫颈癌患者具有较好的近期疗效,可显著改善其性激素水平,控制胃肠道反应等。值得临床加以进一步研究与应用。
Objective To explore the effect of triptolide with interventional embolization chemotherapy on sex hormone levels and long-term survival of cervical cancer patients.Methods A total of 62 patients with cervical cancer admitted between June 2020 and June 2022 were randomly divided into the conventional group(31 cases)and the combined group(31 cases).All patients were given conventional symptomatic treatment and interventional embolization chemotherapy,while patients in the combined group was additionally given triptolide.The short-term remission rate,sex hormone levels at different time points,adverse events and long-term follow-up results in the two groups were observed and compared.Results The total remission rate in the combined group after treatment was significantly higher than that of the conventional group(83.87%vs 58.06%,P<0.05).After half a year of chemotherapy,estrogen(E2)levels significantly decreased in both groups,and significantly lower in the combined group than the conventional group(P<0.05).Follicle-stimulating hormone(FSH)and luteinizing hormone(LH)levels in the combined group significantly decreased,while the levels of FSH and LH in the conventional group significantly increased after treatment(P<0.05).Half a year after the chemotherapy,FSH,E2 and LH levels in the combined group were restored to the pre-chemotherapy levels.FSH and LH levels in the conventional group significantly decreased and E2 levels significantly increased(P<0.05).The incidence of gastrointestinal reactions in the combined group was significantly lower than that of the conventional group(P<0.05).There were no significant differences in the 3-year survival rate(67.74%vs 54.84%)and the local recurrence rate(9.68%vs 25.81%)between groups(P>0.05).The distant metastasis rate in the combined group was significantly lower than that of the conventional group(3.23%vs 19.35%,P<0.05).Conclusion The combination of triptolide and transcatheter arterial chemoembolization has a good short-term effect in cervical cancer patients,which can significantly improve their sex hormone levels and gastrointestinal reactions.It is worth further clinical research and application.
作者
闫丽丽
张雅莉
张莉
毕胜利
YAN Lili;ZHANG Yali;ZHANG Li(Department of Oncology,the Second Affiliated Hospital of Hebei North University,Hebei,Zhangjiakou 075100,China;不详)
出处
《河北医药》
CAS
2024年第20期3124-3127,3131,共5页
Hebei Medical Journal
基金
张家口市重点研发计划项目大健康和生物医疗专项(编号:2021119D)。
关键词
雷公藤甲素
介入栓塞化疗
宫颈癌
近期缓解率
性激素
远期生存情况
triptolide
interventional embolization chemotherapy
cervical cancer
short-term remission rate
sex hormone
long-term survival
