摘要
目的分析在肝硬化诊断中合用天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、胆碱酯酶(cholinesterase,CHE)、总胆红素(total bilirubin,TBIL)、谷丙转氨酶(alanine sminotransferase,ALT)、血清白蛋白(albumin,ALB)诊断的价值。方法非随机选取吉林市第二人民医院于2021年1月—2023年1月期间接收的82例肝硬化患者和60例健康体检人员作为研究对象,全部经生化检验测得其AST、CHE、TBIL、ALT、ALB水平,对比健康体验人员与肝硬化患者各生化指标间的差异,并分析AST联合CHE、TBIL、ALT、ALB诊断肝硬化的价值。结果肝硬化组CHE(2009.27±80.06)U/L、ALB(20.14±2.14)g/L水平均低于健康组,且AST(57.69±7.96)U/L、ALT(66.35±5.06)U/L、TBIL(93.56±8.42)μmol/L均高于健康组,差异有统计学意义(t=202.078、36.785、34.264、70.103、73.899,P均<0.05);AST联合CHE、TBIL、ALT、ALB诊断肝硬化患者的曲线下面积(area under curve,AUC)为0.894、特异度为90.04%、灵敏度为89.56%,均高于各指标单一检测的AUC、特异度及灵敏度。结论AST、CHE、TBIL、ALT、ALB等指标联合对肝硬化患者进行检测,能够进一步提高诊断价值,为临床早期诊治提供参考依据。
Objective The diagnostic value of aspartate aminotransferase(AST),cholinesterase(CHE),total bilirubin(TBIL),alanine aminotransferase(ALT)and albumin(ALB)in the diagnosis of liver cirrhosis was analyzed.Methods From January 2021 to January 2023,eighty-two patients with liver cirrhosis and sixty healthy people in the Second People's Hospital of Jilin City were non-randomly selected as the research objects.The levels of AST,CHE,TBIL,ALT and ALB were measured by biochemical tests.The differences of biochemical indexes between healthy people and patients with liver cirrhosis were compared,and the value of AST combined with CHE,TBIL,ALT and ALB in the diagnosis of liver cirrhosis was analyzed.Results The levels of CHE(2009.27±80.06)U/L and ALB(20.14±2.14)g/L in the cirrhosis group were lower than those in the healthy group,and AST(57.69±7.96)U/L,ALT(66.35±5.06)U/L,TBIL(93.56±8.42)μmol/L were higher than those in the healthy group,the differences were statistically significant(t=202.078,36.785,34.264,70.103,73.899,all P<0.05).The area under curve(AUC),specificity and sensitivity of AST combined with CHE,TBIL,ALT and ALB in the diagnosis of liver cirrhosis were 0.894,90.04%and 89.56%,respectively,which were higher than those of single detection of each index.Conclusion The combined detection of AST,CHE,TBIL,ALT,ALB and other indicators in patients with cirrhosis can further improve the diagnostic value and provide reference for early clinical diagnosis and treatment.
作者
李兵
LI Bing(Department of Clinical Laboratory,The Second People's Hospital-Tumour Hospital of Jilin City,Jilin 132001,Jilin,China)
出处
《系统医学》
2024年第18期163-166,共4页
Systems Medicine
关键词
肝硬化
天门冬氨酸氨基转移酶
胆碱酯酶
总胆红素
谷丙转氨酶
白蛋白
诊断效能
Cirrhosis
Aspartate aminotransferase
Cholinesterase
Total bilirubin
Glutamic-pyruvic transaminase
Albumin
Diagnostic efficacy
