摘要
目的探讨生长抑素联合奥美拉唑治疗急性上消化道出血(AUGH)的疗效及安全性。方法回顾性抽取2020年10月至2023年10月商洛市中心医院收治的AUGH患者78例,按治疗方案将其分为参照组(39例,给予奥美拉唑治疗)和研究组(39例,给予生长抑素、奥美拉唑联合治疗)。比较两组疗效、止血时间、输血量、72 h内再出血率、治疗后Rockall危险性评分及凝血功能指标[纤维蛋白原(Fbg)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、不良反应发生情况。结果研究组总有效率(94.87%,37/39)高于参照组(79.49%,31/39),P<0.05。研究组止血时间短于参照组,输血量少于参照组,72 h内再出血率(2.56%,2/39)低于参照组(20.51%,8/39),P均<0.05。治疗后,研究组Rockall危险性评分低于参照组,Fbg水平高于参照组,PT、APTT水平低于参照组,P均<0.05。研究组不良反应总发生率(12.82%,5/39)与参照组(7.69%,3/39)比较,差异未见统计学意义(P>0.05)。结论生长抑素联合奥美拉唑治疗AUGH疗效显著,能有效降低疾病危险度,修复凝血功能,且有一定安全性。
Objective To investigate the efficacy and safety of somatostatin combined with omeprazole in the treatment of acute upper gastrointestinal haemorrhage(AUGH).Methods A total of 78 patients with AUGH admitted to Shangluo Central Hospital from October 2020 to October 2023 were retrospectively selected,and they were divided into the control group(39 cases,treated with omeprazole)and the study group(39 cases,treated with somatostatin combined with omeprazole)according to the treatment plan.The treatment efficacy,hemostasis time,blood transfusion volume,rebleeding rate within 72 hours,postoperative Rockall risk score,coagulation function indexes including fibrinogen(Fbg),prothrombin time(PT)and activated partial thromboplastin time(APTT),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the study group(94.87%,37/39)was higher than that of the control group(79.49%,31/39),P<0.05.The hemostasis time of the study group was shorter than that of the control group,the blood transfusion volume in the study group was less than that in the control group,and the rebleeding rate within 72 hours of the study group(2.56%,2/39)was lower than that of the control group(20.51%,8/39),all P<0.05.After treatment,the study group had lower Rockall risk score,higher Fbg level,lower PT level and lower APTT level compared with the control group(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the study group(12.82%,5/39)and the control group(7.69%,3/39),P>0.05.Conclusions The combination of somatostatin and omeprazole has significant efficacy in the treatment of AUGH,which can effectively reduce the risk of disease and restore coagulation function,with a certain safety.
作者
樊洁
辛建锋
杨欢
Fan Jie;Xin Jianfeng;Yang Huan(Department of Gastroenterology,Shangluo Central Hospital,Shangluo 726000,China;Department of Spleen and Stomach,Shangluo Traditional Chinese Medicine Hospital,Shangluo 726000,China)
出处
《中国实用医刊》
2024年第18期93-96,共4页
Chinese Journal of Practical Medicine
关键词
生长抑素
奥美拉唑
急性上消化道出血
Somatostatin
Omeprazole
Acute upper gastrointestinal haemorrhage
