摘要
支气管肺发育不良(Bronchopulmonary dysplasia,BPD)是早产儿最常见的并发症。由于炎症的多因素原因,BPD的有效治疗方法仍需探究。有研究表明维生素A可能降低BPD的发病风险,但有关维生素A的作用机制研究较少。由于维生素A主要在妊娠晚期积累,肺部的正常生长和修复以及呼吸系统的完整性都需要维生素A,早产儿出生时维生素A水平可能较低,这可能会增加患BPD的风险。国内外多项研究表明维生素A对BPD疗效,但仍存在争议。本文就维生素A防治BPD的研究进展进行综述,对维生素A在早产儿中的作用进行分析,以期为临床治疗提供参考。
Bronchopulmonary dysplasia(BPD)remains the most common complication of preterm birth.Due to the multifactorial causes of inflammation,effective treatments for BPD needs to be explored.There are studies indicating that vitamin A may reduce the risk of premature infants developing BPD.But information on the mechanism of action of vitamin A is still limited.Because vitamin A accumulates mainly in late gestation,preterm infants may be born with low vitamin A levels,which may increase the risk of BPD.Vitamin A is required for normal lung growth and repair as well as for respiratory system integrity.Many studies at home and abroad have suggested that vitamin A may reduce the risk of BPD,but remains controversial.Therefore,there is a need to comprehensively evaluate the effectiveness and safety of vitamin A as a supplementation in the treatment of preterm infants.This paper reviews the progress of research on vitamin A for the prevention and treatment of BPD.A new analysis of the role of vitamin A in preterm infants is presented to provide a reference for clinical treatment.
作者
张珂
汪凌燕
仇鹏业
饶兴愉
ZHANG Ke;WANG Ling-yan;QIU Peng-ye;RAO Xing-yu(The First Clinical Medical School of Gannan Medical University;Children's Medical Center,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医科大学学报》
2024年第10期1083-1087,共5页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
