摘要
目的探究对妊娠期糖尿病患者实施地特胰岛素、门冬胰岛素治疗法,对其血糖控制和并发症的影响。方法选取2020年1月—2023年1月本院收治的88例妊娠期糖尿病患者为研究对象,利用双盲法等比例地将其分为对照组和观察组,每组44例。对照组皮下注射地特胰岛素注射液,观察组给予门冬胰岛素,对比两组患者空腹血糖(FPG)、餐后2h血糖(2h PG)、全天血糖、糖脂代谢指标、不良反应、母婴结局。结果治疗前,两组患者FPG、2h PG、HbA1c指标对比,差异无统计学意义(P>0.05);治疗后,对照组FPG低于观察组,2h PG、HbA1c均高于观察组(P<0.05)。治疗前,两组患者血糖高峰值与低谷值对比,差异无统计学意义(P>0.05);治疗后,对照组全天内血糖平均值低于观察组(P<0.05)。治疗前,两组患者LDL-C、HDL-C、TC、TG指标对比差异无统计学意义(P>0.05);治疗后,观察组患者LDL-C、HDL-C、TC均高于对照组,TG指标低于对照组(P<0.05)。治疗后,观察组血压异常、恶心呕吐、皮肤过敏反应、营养障碍总不良反应发生率与对照组对比,差异无统计学意义(P>0.05);观察组患者整体不良母婴结局发生率高于对照组,但结果不具有统计学意义(P>0.05)。结论妊娠期糖尿病患者采用地特胰岛素治疗法,全天血糖和空腹血糖的控制效果显著。门冬胰岛素控制患者餐后血糖效果显著,但临床中需结合患者实际情况科学用药,才能有效控制患者血糖,改善母婴结局。
Objective To explore effect of insulin detemir and insulin aspart on blood glucose control and complications of patients with gestational diabetes.Methods The paper chose 88 patients with gestational diabetes in our hospital from January 2020 to January 2023 as research objects,and divided them into control group and observation group in equal proportion with double blind method,with 44 cases in each group.Control group was treated with subcutaneous injection of insulin detemir,and observation group with insulin aspart.Fasting blood glucose(FPG),postprandial blood glucose(2hPG),whole day blood glucose,glucose and lipid metabolism indicators,adverse reactions,and maternal and infant outcomes were compared between two groups.Results Before treatment,there was no difference in comparison of FPG,2hPG HbA1c indicators between two groups,(P>0.05).After treatment,FPG of control group was lower than observation group,2-hour PG HbA1c was higher than observation group(P<0.05).Before treatment,there was no significant difference between peak and trough blood glucose levels between two groups,with no statistical significance(P>0.05).After treatment,average daily blood glucose level in control group was lower than observation group(P<0.05).Before treatment,there was no difference in comparison of LDL-C,HDL-C,TC,and TG indicators between two groups,(P>0.05).After treatment,observation group had higher LDL-C HDL-C and TC than control group,and TG index was lower than control group(P<0.05).After treatment,there was no difference in incidence of abnormal blood pressure,nausea and vomiting,skin allergic reactions,and total adverse reactions to nutritional disorders between observation group and control group(P>0.05).Overall incidence of adverse maternal and infant outcomes in observation group was higher than control group,results were not statistically significant(P>0.05).Conclusion Insulin detemir can achieve significant effect in control of whole day blood sugar and fasting blood sugar of patients with gestational diabetes,and insulin aspart can achieve significant effect in control of postprandial blood sugar.During clinical practice,it is necessary to combine actual situation of patients and use drugs scientifically to reduce and control blood sugar and improve maternal and infant outcomes effectively.
作者
黄竹青
HUANG Zhuqing(Obstetrics and Gynecology Department,Zhangye City Shandan County Maternal and Child Health Hospital,Zhangye,Gansu 734100)
出处
《智慧健康》
2024年第20期79-82,共4页
Smart Healthcare
