摘要
我国多数胃癌患者在确诊时已处于中晚期,针对晚期胃癌的综合治疗显得至关重要。全身药物治疗是晚期胃癌的主要治疗手段,在精准医疗的理念下,如HER2阳性患者的德曲妥珠单抗治疗,以及免疫治疗如纳武利尤单抗联合化疗,均显著改善了晚期胃癌患者的生存期。同时,局部治疗、营养和社会心理支持也提高了患者的生活质量。本文综合讨论了晚期胃癌围手术期治疗、缩小淋巴结清扫范围及去手术治疗的可行性,并强调多学科综合治疗模式的重要性,以期实现晚期胃癌患者的个体化、精准化治疗。
In China,most patients with gastric cancer are diagnosed at an advanced stage,making comprehensive treatment for advanced gastric cancer crucial.Systemic pharmacotherapy is the mainstay treatment for such patients.Guided by the concept of precision medicine,trastuzumab deruxtecan for HER2-positive patients and immunotherapy,such as nivolumab in combination with chemotherapy,have significantly improved the survival outcomes of patients with advanced gastric cancer.Furthermore,local therapy,nutritional support,and psychosocial interventions have enhanced patient quality of life.Herein,the perioperative treatment strategies,feasibility of reduced lymphadenectomy,and surgery-sparing approaches are explored,emphasizing the importance of a multidisciplinary treatment models to achieve individualized and precise treatment for patients with advanced gastric cancer.
作者
高鸿超
彭智
Hongchao Gao;Zhi Peng(Department of Digestive Oncology,Peking University Cancer Hospital&Institute,State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Beijing Key Laboratory of Carcinogenesis and Translational Research,Beijing 100142,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2024年第17期896-901,共6页
Chinese Journal of Clinical Oncology
关键词
晚期胃癌
综合治疗
转化治疗
局部治疗
多学科治疗
advanced gastric cancer
comprehensive therapy
conversion therapy
local therapy
multidisciplinary therapy
