摘要
胚胎植入是妊娠过程中的重要限速步骤,是一个动态发育的过程,包括胚胎和子宫内膜细胞间的一系列细胞间通信及相互作用。外泌体是细胞外囊泡的一种亚型,广泛存在于细胞及体液中,可作为新的细胞间通信介质在体内发挥作用。研究表明,外泌体可参与调节胚胎发育、子宫内膜容受性、胚胎黏附、免疫耐受和血管生成等多个过程,在复杂的胚胎植入过程中发挥着重要作用。本文将对外泌体在胚胎植入中的作用进行综述,为深入探究人类胚胎植入失败原因提供新的思路。
Embryo implantation,as an important speed limiting step in pregnancy,is a dynamic developmental process that involves a series of intercellular communication and interactions between the embryo and endometrial cells.Exosomes are a subtype of extracellular vesicles that are widely present in cells and bodily fluids and can serve as new intercellular communication mediators in the body.Research has shown that exosomes can participate in regulating embryonic development,endometrial receptivity,embryo adhesion,immune tolerance,and angiogenesis,playing an important role in regulating complex embryo implantation processes.This article will review the role of exosomes in embryo implantation,in order to provide new insights into the failure of embryo implantation in human reproduction.
作者
王祎玟
杨淑珺
李艳如
王倩
张翠莲
Wang Yiwen;Yang Shujun;Li Yanru;Wang Qian;Zhang Cuilian(Reproductive Medicine Center,Zhengzhou University People's Hospital,Henan University People's Hospital,Henan Provincial People's Hospital,Zhengzhou 450003,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2024年第10期1092-1097,共6页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金(U2004130)
河南省医学科技攻关计划联合共建项目(LHGJ20220045)。
关键词
外泌体
胚胎植入
细胞间通信
Exosomes
Embryo implantation
Cell communication
