摘要
Electrospun nanofibrous membranes(eNFMs)have been extensively developed for bio-applications due to their structural and compositional similarity to the natural extracellular matrix.However,the emergence of antibiotic resistance in bacterial infections significantly impedes the further development and applications of eNFMs.The development of antibacterial nanomaterials substantially nourishes the engineering design of antibacterial eNFMs for combating bacterial infections without relying on antibiotics.Herein,a comprehensive review of diverse fabrication techniques for incorporating antibacterial nanomaterials into eNFMs is presented,encompassing an exhaustive introduction to various nanomaterials and their bactericidal mechanisms.Furthermore,the latest achievements and breakthroughs in the application of these antibacterial eNFMs in tissue regenerative therapy,mainly focusing on skin,bone,periodontal and tendon tissues regeneration and repair,are systematically summarized and discussed.In particular,for the treatment of skin infection wounds,we highlight the antibiotic-free antibacterial therapy strategies of antibacterial eNFMs,including(i)single model therapies such as metal ion therapy,chemodynamic therapy,photothermal therapy,and photodynamic therapy;and(ii)multimodel therapies involving arbitrary combinations of these single models.Additionally,the limitations,challenges and future opportunities of antibacterial eNFMs in biomedical applications are also discussed.We anticipate that this comprehensive review will provide novel insights for the design and utilization of antibacterial eNFMs in future research.
基金
supported by the National Natural Science Foundation of China(82172211,92268206)
the National Key Research and Development Programs of China(2022YFA1104300)
the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-059)
the Military Medical Research Projects(2022-JCJQ-ZB-09600,2023-JSKY-SSQG-006)
the Natural Science Foundation of Sichuan Province(2023NSFSC0339)
the 1·3·5 Project for Disciplines of Excellence of West China Hospital,Sichuan University(ZYGD22008)
the China Postdoctoral Science Foundation(2022TQ0223,2022M722256)
the Post-Doctor Research Project of West China Hospital,Sichuan University(2023HXBH031).
