摘要
目的探究己酮可可碱及胰岛素联合治疗早期2型糖尿病肾病的影响。方法选取2021年6月—2024年3月潍坊内分泌与代谢病医院收治的84例早期2型糖尿病肾病患者为研究对象,按照治疗方法不同分为两组,各42例。对照组采用胰岛素治疗,观察组采用己酮可可碱及胰岛素联合治疗。对比两组临床疗效、肾小管尿相关指标、肾功能、血糖指标及不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组尿渗量比较,差异无统计学意义(P>0.05);观察组β2-微球蛋白、N-乙酰-β-D氨基葡萄糖苷酶水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组肌酐、尿素氮、尿α1微球蛋白、视黄醇结合蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论己酮可可碱联合胰岛素治疗早期2型糖尿病肾病疗效确切,肾小管尿相关指标及肾功能均得以有效改善,安全性较高。
Objective To explore the effect of pentoxifylline combined with insulin in the treatment of early type 2 diabetes nephropathy.Methods A total of 84 patients with early type 2 diabetes nephropathy admitted to Weifang Endocringology and Metabolic Disease Hospital from June 2021 to March 2024 were selected as the research objects and divided into two groups according to different treatment methods,with 42 cases in each group.The control group was treated with insulin,and the observation group was treated with pentoxifylline and insulin.The clinical efficacy,renal tubular urine related indicators,renal function,blood glucose indicators and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,there was no significant difference in urine leakage between the two groups(P>0.05).The levels ofβ2-microglobulin and N-acetyl-β-D-glucosaminidase in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the levels of creatinine,urea nitrogen,urinaryα1 microglobulin and retinol binding protein in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Pentoxifylline combined with insulin is effective in the treatment of early type 2 diabetes nephropathy,and the related indexes of renal tubular urine and renal function are effectively improved,with high safety.
作者
于洋
谭晓辉
范婷婷
张淑霞
张苗
YU Yang;TAN Xiaohui;FAN Tingting;ZHANG Shuxia;ZHANG Miao(Department of Nephrology,Weifang Endocrinology and Metabolic Disease Hospital,Weifang 262600,Shandong,China;Department of Physical Therapy,Weifang Endocrinology and Metabolic Disease Hospital,Weifang 262600,Shandong,China;Department of Traditional Chinese Medicine Rehabilitation,Shouguang Hexin Hospital,Weifang 262700,Shandong,China;Department of Internal Medicine,Weifang Endocrinology and Metabolic Disease Hospital,Weifang 262600,Shandong,China)
出处
《糖尿病新世界》
2024年第19期9-12,共4页
Diabetes New World
基金
2024年市卫健委科研项目计划(WFWSJK-2024-222)。
关键词
早期2型糖尿病肾病
己酮可可碱
胰岛素
疗效
肾功能
Early type 2 diabetes nephropathy
Pentoxifylline
Insulin
Efficacy
Renal function
