摘要
目的探讨1990-2019年中国0~14岁儿童肿瘤疾病负担的变化趋势及其主要来源。方法采用全球健康数据交换(GHDx)数据库数据,分性别、年龄分析1990-2019年中国和全球儿童肿瘤发病率、死亡率和伤残调整寿命年(DALY)率情况。采用Joinpoint法分析儿童肿瘤发病率、死亡率和DALY率的年度变化百分比(APC)和平均年度变化百分比(AAPC)。结果1990-2019年中国儿童肿瘤疾病负担各项指标均呈下降趋势,发病率平均每年变化-3.28%(-3.61%,-2.95%),死亡率平均每年变化-3.29%(-3.53%,-3.05%),DALY率平均每年变化-3.29%(-3.52%,-3.05%),均P<0.001;各指标整体趋势均被分为6个区段。发病率下降6.58%、伤残损失寿命年(YLD)率下降22.89%,低于全球总体下降幅度;死亡率下降62.17%、DALY率下降62.04%、过早死亡寿命损失年(YLL)率下降60.7%,下降幅度均高于全球总体水平。中国发病率处于较低水平,但死亡率和DALY率远高于美国等发达国家。各年龄组中0~28 d组疾病负担各指标值均为最高,且各指标随年龄增长呈下降趋势;疾病负担指标存在性别差异。中国儿童肿瘤发病率、死亡率和DALY率最高的均是白血病,儿童肿瘤发病率顺位具有性别差异。结论1990-2019年中国儿童肿瘤疾病负担呈下降趋势,过早死亡是疾病负担的主要来源,疾病负担存在性别和年龄差异。
Objective To investigate the changing trend and main sources of pediatric cancer disease burden in 0-14 year old children in China from 1990 to 2019.Methods Data from Global Health Data Exchange(GHDx)database were used to analyze the incidence,mortality and disability-adjusted life year(DALY)rates of pediatric cancer in China and the world from 1990 to 2019 by sex and age.The Joinpoint method was used to analyze the annual percentage change(APC)and average annual percentage change(AAPC)in pediatric cancer incidence,mortality and DALY rates.Results From 1990 to 2019,all indicators of the burden of childhood tumor disease in China showed a downward trend,with the average annual change of incidence rate of-3.28%(-3.61%,-2.95%),the average annual change of mortality rate of-3.29%(-3.53%,-3.05%),and the average annual change of DALY rate of-3.29%(-3.52%,-3.05%),all P<0.001;The overall trend of each indicator was divided into 6 sections.The incidence rate decreased by 6.58%,the years of lived with disability(YLD)rate decreased by 22.89%,which were lower than the global overall decrease rate,the mortality rate decreased by 62.17%,the DALY rate decreased by 62.04%,and the years of life lost(YLL)rate decreased by 60.7%,which were higher than the global overall decrease rate.The incidence in China was at a low level,but the mortality and DALY rates were much higher than those in developed countries such as the United States.Among all age groups,the indexes of disease burden in 0-28 d group were the highest,and the indexes showed a decreasing trend with the increase of age.There were gender differences in disease burden indicators.In China,leukemia was the highest in incidence,mortality,and DALY rates of childhood tumors,and the order of incidence rates in childhood cancer exhibited a gender difference.Conclusions The burden of cancer in children in China showed a decreasing trend from 1990 to 2019.Premature death was the main source of the burden of cancer,and there were gender and age differences in the burden.
作者
秦畅
胡筱玙
祝健彪
刘晓璇
崔永春
QIN Chang;HU Xiaoyu;ZHU Jianbiao;LIU Xiaoxuan;CUI Yongchun(School of Public Health,Shandong Second Medical University,Weifzng,Shzndong 261053,Chinz;School of Public Health,Shandong First Medical University,Jinzn,Shzndong 250117,Chinz;Department of Public Health,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinzn,Shzndong 250117,Chinz)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2024年第15期913-919,共7页
Chinese Journal of Cancer Prevention and Treatment
关键词
儿童肿瘤
疾病负担
伤残调整寿命年
变化趋势
疾病负担
pediatric tumor
disease burden
disability adjusted life years
trends of change
burden of disease
