摘要
目的:分析Toll样受体(TLRs)、白细胞介素-6(IL-6)水平对气虚血瘀型急性缺血性脑卒中患者疗效的预测价值。方法:选择550例急性缺血性脑卒中患者为研究对象,比较不同证型间患者血清TLR2、TLR3、IL-6水平;统计气虚血瘀型急性缺血性脑卒中患者疗效,并根据疗效分为有效组与无效组,单因素及多因素Logistic回归分析影响气虚血瘀型急性缺血性脑卒中患者疗效的相关因素,分析血清TLR2、TLR3、IL-6水平对气虚血瘀型急性缺血性脑卒中疗效的预测价值。结果:不同证型间急性缺血性脑卒中患者血清TLR2、TLR3、IL-6水平比较,差异有统计学意义(P<0.05)。Logistic分析显示,大动脉粥样硬化血管狭窄、中国缺血性卒中分型(CISS)、早期神经功能恶化、血清TLR2、TLR3、IL-6水平均是影响气虚血瘀型急性缺血性脑卒中患者疗效的危险因素(P<0.05)。血清TLR2、TLR3、IL-6水平预测气虚血瘀型急性缺血性脑卒中患者疗效的曲线下面积(AUC)分别为0.881、0.832、0.771,而三者联合预测气虚血瘀型急性缺血性脑卒中患者疗效的AUC为0.948,明显大于三者单独预测(P<0.05)。结论:急性缺血性脑卒中患者血清TLR2、TLR3、IL-6水平在不同中医证型中差异较大,三者同时检测可有效预测气虚血瘀型急性缺血性脑卒中患者疗效。
Objective:To analyze the predictive value of Toll-like receptors(TLRs)and interleukin-6(IL-6)levels for the therapeutic effect in the treatment of acute ischemic stroke of qi deficiency and blood stasis type.Methods:A total of 550 cases of patients with acute ischemic stroke were selected as the research subjects,and the levels of serum TLR2,TLR3,and IL-6 were compared among patients with different syndrome types.After counting the curative effects on acute ischemic stroke patients with qi deficiency and blood stasis type,the patients were divided into the effective group and the ineffective group based on the curative effects.Univariate and multivariate Logistic regression analyses were conducted to identify the relevant factors affecting the curative effects on acute ischemic stroke patients with qi deficiency and blood stasis type,and the predictive value of levels of serum TLR2,TLR3,and IL-6 for the therapeutic effect in the treatment of acute ischemic stroke with qi deficiency and blood stasis type was analyzed.Results:There was a significant difference being found in the levels of serum TLR2,TLR3,and IL-6 among patients with acute ischemic stroke of different syndrome types(P<0.05).Logistic analysis showed that atherosclerotic vascular stenosis,Chinese Ischemic Stroke Classification(CISS),early neurological deterioration,and levels of serum TLR2,TLR3,and IL-6 were risk factors affecting the curative effects in the treatment of patients with acute ischemic stroke of qi deficiency and blood stasis type(P<0.05).The area under the curve(AUC)of serum TLR2,TLR3,and IL-6 levels predicting the curative effects in the treatment of acute ischemic stroke patients with qi deficiency and blood stasis type were 0.881,0.832,and 0.771,respectively.However,the AUC of the combined prediction of the three levels for the curative effects in the treatment of acute ischemic stroke of qi deficiency and blood stasis type was 0.948,which was significantly higher than their individual predictions(P<0.05).Conclusion:The levels of serum TLR2,TLR3,and IL-6 in patients with acute ischemic stroke vary greatly among different traditional Chinese medicine syndrome types.Simultaneous detection of the three indicators can effectively predict the therapeutic effect in the treatment of acute ischemic stroke with qi deficiency and blood stasis type.
作者
吴剑红
王俊
戴姗珊
董国丽
WU Jianhong;WANG Jun;DAI Shanshan;DONG Guoli(Department of Neurosurgery,Linping Campus,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou Zhejiang 311100,China)
出处
《新中医》
CAS
2024年第23期25-29,共5页
New Chinese Medicine
基金
浙江省医药卫生科技计划项目(2020KY800)。
