摘要
背景:研究表明内质网应激引起的缺血半暗带区神经细胞自噬是脑缺血再灌注损伤的关键环节,内质网跨膜蛋白PERK、IRE1α、ATF6与GRP78/BIP解离激活后介导的细胞自噬对神经元的转归起着重要作用。而中药可通过调控内质网应激-自噬,减少神经元损伤或死亡,发挥脑保护作用。目的:探讨内质网应激-自噬在脑缺血再灌注损伤中的作用及中药调控机制研究进展。方法:以“脑缺血再灌注损伤,脑损伤,缺血性中风,内质网应激、自噬,中药,复方,信号通路,皂苷,多酚,生物碱”为中文检索词,以“cerebral ischemia-reperfusion injury,ischemic stroke,brain injury,endoplasmic reticulum stress,autophagy,traditional Chinese medicine,compounds,signaling pathways,saponins,polyphenols,alkaloids”为英文检索词,检索2015年1月至2024年5月中国知网以及PubMed数据库中有关内质网应激、自噬与脑缺血再灌注损伤及中药调控机制的文献,排除与研究内容不相符、过时及重复的文献。共检索出1197篇相关文献,最终纳入71篇文献进行综述分析。结果与结论:①大量研究结果表明,内质网应激-自噬与脑缺血再灌注损伤密切相关;②中药单体有效成分及复方可通过调控PERK-eIF2α-ATF4、IRE1α-ASK1-JNK、IRE1α-XBP等信号通路调节内质网应激-自噬相关蛋白表达,减轻神经细胞损伤,发挥脑保护作用。
BACKGROUND:Research has shown that endoplasmic reticulum stress-induced autophagy of neurons in the ischemic penumbra is a key link in cerebral ischemia-reperfusion injury.Autophagy mediated by the dissociation and activation of endoplasmic reticulum transmembrane proteins PERK,IRE1α,ATF6,and GRP78/BIP plays an important role in neuronal outcomes.Traditional Chinese medicine can regulate endoplasmic reticulum stress-autophagy,reduce neuronal damage or death,and exert neuroprotective effects.OBJECTIVE:To explore the role of endoplasmic reticulum stress-autophagy in cerebral ischemia-reperfusion injury and the research progress in the regulatory mechanisms of traditional Chinese medicine.METHODS:A literature retrieval was conducted in CNKI and PubMed for relevant literature related to endoplasmic reticulum stress,autophagy,cerebral ischemia-reperfusion injury,and regulation by traditional Chinese Medicine published from January 2015 to May 2024.The search terms were“cerebral ischemia-reperfusion injury,ischemic stroke,brain injury,endoplasmic reticulum stress,autophagy,traditional Chinese medicine,compounds,signaling pathways,saponins,polyphenols,alkaloids”in Chinese and English,respectively.Any literature that is inconsistent with the research content,outdated,or duplicated was excluded.A total of 1197 relevant literature were retrieved,and 71 articles were ultimately included.RESULTS AND CONCLUSION:(1)Numerous studies have suggested that endoplasmic reticulum stress-autophagy is closely related with cerebral ischemia-reperfusion injury.(2)The active ingredients and compound formulas of traditional Chinese medicine monomers can regulate the expression of endoplasmic reticulum stress-autophagy related proteins,alleviate neuronal damage,and exert neuroprotective effects by regulating signal pathways such as PERK-eIF2α-ATF4,IRE1α-ASK1-JNK,and IRE1α-XBP.
作者
张硕
崔应麟
周盼盼
李毅乐
王蕾
邹倩倩
Zhang Shuo;Cui Yinglin;Zhou Panpan;Li Yile;Wang Lei;Zou Qianqian(The Second Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450002,Henan Province,China;Famous Doctor Hall,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,Henan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2025年第20期4325-4332,共8页
Chinese Journal of Tissue Engineering Research
基金
国家中医药管理局2022年第二届全国名中医传承工作室建设项目(国中医药办人教函[2022]245号),项目负责人:崔应麟
中医元气学说体系建设及其免疫相关疾病的防治(GZY-KJS-2021-017),项目负责人:崔应麟
河南省重点研发专项立项(221111310500),项目负责人:崔应麟。
关键词
内质网应激
自噬
脑缺血再灌注损伤
内质网跨膜蛋白
中药
信号通路
工程化组织构建
endoplasmic reticulum stress
autophagy
cerebral ischemia-reperfusion injury
endoplasmic reticulum transmembrane protein
traditional Chinese medicine
signal pathway
engineered tissue construction
