摘要
采用溶液流延法,以冰醋酸为溶剂、戊二醛为交联剂、壳聚糖为载体、姜黄素为药物模型,制备了姜黄素/壳聚糖药物薄膜。通过红外、热重分析方法分析了复合材料的组份和热稳定性,同时研究了药物薄膜的吸水性、载药性和缓释性。结果表明,当未添加戊二醛溶液时,药物薄膜的平衡溶胀度为(406.67±0.51)%;当戊二醛溶液添加量为4%(体积比)时,平衡溶胀度下降到(186±2.46)%;在实验配方范围内,当戊二醛溶液添加量为3%、壳聚糖浓度为2%、姜黄素添加量为2%、时间为20 h时,薄膜的药物释放率为66.91%,因此,薄膜具有一定的缓释能力;另外,分析了药物薄膜的缓释机制,发现,该体系的药物释放机制基本符合一级方程模型,拟合方程为M_t=73.56167(1-e-0.13846 t)。
Curcumin/chitosan drug film was prepared using a solution casting method with glacial acetic acid as the solvent,glutaraldehyde as the crosslinking agent,chitosan as the carrier,and curcumin as the drug model.The components and thermal stability of the composite material were investigated by infrared spectroscopy and thermogravimetry.In addition,the water absorption,drug loading and sustained release properties of the drug film were evaluated.It was found that at a glutaraldehyde concentration of 0,the equilibrium swelling degree of the drug film was(406.67±0.51)%,while at a glutaraldehyde concentration of 4%(volume ratio),the equilibrium swelling degree decreased to(186±2.46)%.Within the experimental formulation range,the optimal glutaraldehyde concentration was 3%,chitosan concentration was 2%,and curcumin loading was 2%.The release rate at 20 hours was 66.91%,indicating that the prepared drug film had a certain sustained-release ability.It was found that the drug release mechanism basically conformed to the first-order equation model,and the fitting equation was M_(t)=73.56167(1-e^(-0.13846 t)).
作者
王培
牛丽丽
李静宇
曹利慧
杨云
WANG Pei;NIU Lili;LI Jingyu;CAO Lihui;YANG Yun(Department of Chemistry,Hengshui University,Hengshui,Hebei 053000,China)
出处
《塑料》
CAS
CSCD
北大核心
2024年第6期28-32,38,共6页
Plastics
基金
衡水市教育科学研究“十四五”规划课题(2205251)
2023年度衡水学院校级重点课题(2023ZRZ06)。
关键词
姜黄素
壳聚糖
药物薄膜
缓释
释放机制
curcumin
chitosan
drug films
sustained release
release mechanism
