摘要
目的分析地特胰岛素+门冬胰岛素对糖尿病直肠癌患者术后血糖控制的影响。方法回顾性选取2023年1月—2024年4月泉州市第一医院收治的120例糖尿病直肠癌患者的临床资料,根据术后控糖治疗方式的不同分为两组,各60例。两组术后实施常规治疗,对照组控糖治疗中采用地特胰岛素睡前皮下注射,研究组在对照组基础上采用门冬胰岛素餐前注射。对比两组血糖水平、氧化应激指标、不良反应发生情况。结果治疗前,两组血糖水平、氧化应激指标对比,差异均无统计学意义(P均>0.05)。治疗后,研究组空腹血糖、餐后2 h血糖、丙二醛水平低于对照组,超氧化物歧化酶水平高于对照组,差异均有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论地特胰岛素联合门冬胰岛素在糖尿病直肠癌患者术后应用中,能够显著降低血糖水平、改善氧化应激状态,并且不良反应风险较低。
Objective To analyze the effect of insulin detemir+insulin aspart on postoperative blood glucose control in patients with diabetic rectal cancer.Methods The clinical data of 120 patients with diabetic rectal cancer admitted to Quanzhou First Hospital from January 2023 to April 2024 were retrospectively selected.They were divided into two groups according to different postoperative glucose control treatment methods,with 60 cases in each group.The two groups were treated with routine treatment after operation,the control group was treated with subcutaneous injection of insulin detemir before bedtime,and the study group was treated with preprandial injection of insulin aspart on the basis of the control group.The blood glucose levels,oxidative stress indexes and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in blood glucose levels and oxidative stress indexes between the two groups(all P>0.05).After treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose and malondialdehyde in the study group were lower than those in the control group,the level of superoxide dismutase was higher than that of control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Insulin detemir combined with insulin aspart can significantly reduce blood glucose level and improve oxidative stress in patients with diabetic rectal cancer after operation,and the risk of adverse reactions is low.
作者
高莹莹
江珍珍
王惠云
GAO Yingying;JIANG Zhenzhen;WANG Huiyun(Department of Gastroenterology 1,N18 District,Quanzhou First Hospital,Quanzhou 362000,Fujian,China)
出处
《糖尿病新世界》
2024年第20期71-73,97,共4页
Diabetes New World
关键词
地特胰岛素
门冬胰岛素
糖尿病
直肠癌
不良反应
Insulin detemir
Insulin aspart
Diabetes mellitus
Rectal cancer
Adverse reaction
