摘要
目的探讨乌司他丁联合胸腺肽α1治疗脓毒症休克合并急性肾损伤的效果。方法抽取本院2021年1月—2023年1月接诊的56例脓毒症休克合并急性肾损伤患者作为研究对象,根据患者自主意愿分为单一组(28例)与联合组(28例),分别行乌司他丁治疗与乌司他丁联合胸腺肽α1治疗,比较两组患者病症改善率、炎症因子、生活质量改善情况。结果相较于单一治疗组,联合治疗组的病症改善率显著较高(P<0.05)。治疗前,患者炎症因子指标的比较显示,两组之间差异无显著统计学意义(P>0.05);治疗后,联合治疗组的控制效果更为显著(P<0.05)。治疗前,两组患者的生活质量指标比较差异无统计学意义(P>0.05);治疗后,联合治疗组患者的生活质量改善效果更为显著(P<0.05),能够有效改善患者的精神状态、生理状态、躯体功能及疼痛程度。结论在临床实践中,采用乌司他丁联合胸腺肽α1治疗脓毒症休克合并急性肾损伤患者,能够显著改善患者的病情,有效降低炎症反应,生活质量得到明显提升,使患者维持良好的生活状态,治疗满意度较高,有助于促进医患关系的和谐发展。
Objective The paper mainly studies patients with sepsis shock combined with acute kidney injury,analyzes clinical effect of combination therapy of ulinastatin and thymosinα1,and improve symptoms of patients.Methods The paper chose 56 patients with septic shock complicated with acute kidney injury in our hospital from January 2021 to January 2023 as experimental study subjects,and divided them into the single group(28 cases)and the combination group(28 cases)according to their voluntary wishes,treated with ulinastatin and ulinastatin combined with thymosinα1 respectively.The improvement rate of symptoms,inflammatory factor indicators,and life quality indicators were compared between two groups.Results There was significant difference in improvement rate between two groups of symptoms(P<0.05),with improvement rates of 71.43%and 96.43%respectively.Before treatment,there was no significant difference in inflammatory cytokine indicators of patients(P>0.05).After treatment,the combination group had more ideal control effect(P<0.05).Before treatment,there was no significant difference in life quality of patients(P>0.05).After treatment,the improvement effect of the combination group was more ideal(P<0.05),which could improve mental state,physiological state,physical function,and pain level of patients effectively.Conclusion Ulinastatin combined with thymosinα1 can improve symptoms,reduce inflammatory reactions effectively,and improve life quality of septic shock patients with acute kidney injury during clinical application,can provide patients with good living condition,with high treatment satisfaction,and promote the harmonious development of doctor-patient relationships.
作者
许伟伟
葛玲玉
朱华
孙卫和
冒秀宏
XU Weiwei;GE Lingyu;ZHU Hua;SUN Wei;MAO Xiuhong(ICU Department,Dongtai City People's Hospital,Dongtai,Jiangsu 224200;Imaging Department,Dongtai City People's Hospital,Dongtai,Jiangsu 224200)
出处
《智慧健康》
2024年第29期102-104,共3页
Smart Healthcare
