摘要
Human cancer is one of the leading causes of death worldwide.Tumor heterogeneity and complex microenvironment are major challenges for anti-cancer treatment.A better understanding of the tumor heterogeneity might contribute to more precise diagnosis and treatment.Recent advances in single-cell RNA-sequencing(scRNA-seq)have provided valuable insights into cell fate determination and development in cancer,but the main limitation is that cellular spatial information is lost.Fortunately,spatially resolved transcriptomics technologies have enabled gene expression profiling with spatial coordinates in tissues,which opens up new avenues for deciphering the cancer spatial structure and accelerating oncological research.
基金
supported by the National Natural Science Foundation of China(62003028)
supported by a Scholarship from the China Scholarship Council。
