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Multidisciplinary integration and fusion based on critical care medicine and immunology:History,current status,and prospects 被引量:1

以危重症医学与免疫学为基础的多学科交叉与融合:历史、现状与展望石坚
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摘要 Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions,including sepsis,severe trauma/burns,hemorrhagic shock,heatstroke,and acute pancreatitis,all of which have high incidence rates.These conditions are primarily characterized by acute multi-organ dysfunction,with sudden onset,severe illness,and high mortality rates.Additionally,critical care treatment demands substantial medical resources,imposing significant economic burdens on patients’families and society.In recent years,critical care medicine has achieved notable progress,especially in multidisciplinary integration with immunology-based fields.Collaboration across disciplines has not only accelerated advancements in critical care but also propelled the rapid development of modern immunology.This paper provides an overview and assessment of the cross-disciplinary fusion between critical care medicine and immunology,exploring how these fields related extensions mutually enhance each other.It further analyzes China’s potential to become a global leader in this area within the next 5 to 10 years. 危重症医学致力于研究危及生命的病理生理状态的发生、发展规律及其诊治方法。脓毒症、严重创伤/烧伤、失血性休克、中暑和重症胰腺炎等的发生率高,其主要特征为急性多器官功能障碍,通常表现为起病急、病情重、病死率高。此外,危重症的治疗需要耗费大量医疗资源,给患者家庭和社会带来了沉重的经济负担。近年来,危重症医学在多个领域取得了显著进展,尤其是在与免疫学为基础的学科交叉融合方面表现尤为突出。多学科与跨学科的协作不仅加速了危重症医学的发展进程,也推动了现代免疫学的快速进步。本文将对危重症医学与免疫学的学科交叉与融合进行简要回顾与评估,初步探讨这两个领域及其相关延伸如何相互促进,并对中国在未来5至10年内成为该领域全球领导者之一的潜力进行分析。
作者 SHI Jian LÜBen 石坚;吕奔(中南大学湘雅三医院,长沙410013;中南大学湘雅二医院,长沙410011)
出处 《中南大学学报(医学版)》 CAS CSCD 北大核心 2024年第8期1327-1332,共6页 Journal of Central South University :Medical Science
基金 supported by the National Science Foundation for Distinguished Young Scholars,China(82025021).
关键词 critical care medicine IMMUNOLOGY SEPSIS cross-disciplinary integration MULTIDISCIPLINARY intensive care 危重症医学 免疫学 脓毒症 跨学科整合 多学科 重症监护
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  • 1Martinon F, Mayor A, Tschopp J. The inflammasomes: guard- ians of the body. Annu Rev Immuno12009; 27:229-265.
  • 2Lamkanfi M, Dixit VM. lnflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol 2012; 28:137- 161.
  • 3Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005; 73:1907-1916.
  • 4Netea MG, Simon A, van de Veerdonk F, et al. IL-lbeta pro- cessing in host defense: beyond the inflammasomes. PLoS Pathog 2010; 6:e1000661.
  • 5Miao EA, Leaf IA, Treuting PM, et al. Caspase-l-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immuno12010; 11 : 1136-1142.
  • 6Lamkanfi M, Dixit VM. Mechanisms and functions of inflam- masomes. Cell 2014; 157:1013-1022.
  • 7Davis BK, Wen H, Ting JP. The inflammasome NLRs inimmunity, inflammation, and associated diseases. Annu Rev Immuno12011; 29:707-735.
  • 8Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140:821-832.
  • 9Dinarello CA. Immunological and inflammatory functions of the interleukin- 1 family. Annu Rev Immunol 2009; 27:519- 550.
  • 10Shi J, Zhao Y, Wang Y, et al. Inflammatory caspases are in- nate immune receptors for intracellular LPS. Nature 2014; 514:187-192.

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