摘要
目的探讨理肺汤联合布地奈德福莫特罗治疗支气管哮喘(BA)患儿的疗效及对气道重塑、血清嗜酸性粒细胞趋化因子(Eotaxin)水平的影响。方法选取2021年9月至2023年12月的112例BA患儿,通过随机数字表法分为中西组、西药组,每组56例。西药组采用布地奈德福莫特罗粉吸入剂,中西组在西药组基础上加用理肺汤治疗。比较两组治疗疗效、中医症状积分、气道重塑指标、血清Eotaxin水平及不良反应发生率。结果中西组患儿的总有效率为92.86%,明显高于西药组的78.57%(P<0.05)。两组治疗后各项中医症状评分均明显降低(P<0.05),且中西组较西药组降低更明显(P<0.05)。两组治疗后,气道重塑相关指标碱性成纤维细胞生长因子(basic fibroblast growth factor,b-FGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、血小板衍生生长因子-BB(platelet-derived growth factor-BB,PDGF-BB)水平均显著下降,且中西组下降幅度显著高于西药组(P<0.05)。两组治疗后血清Eotaxin水平均显著下降,且中西组显著低于西药组(P<0.05)。西药组、中西组总不良反应发生率分别为14.29%、8.93%,组间比较差异无统计学意义(P>0.05)。结论理肺汤联合布地奈德福莫特罗治疗BA患儿,能产生较好的临床疗效,有效改善患儿中医证候及支气管功能,抑制气道重塑,安全性较高。
Objective To investigate the efficacy of Lifei Decoction combined with Budesonide/Formoterol in treating bronchial asthma(BA)in children and its effects on airway remodeling and serum Eotaxin levels.Methods A total of 112 children with BA from September 2001 to December 2023 were randomly divided into two groups:the TCM-western medicine group(n=56)and the western medicine group(n=56).The western medicine group received Budesonide/Formoterol inhalation,while the TCM-western medicine group received Lifei Decoction in addition to the inhalation treatment.The two groups were compared regarding treatment efficacy,traditional Chinese medicine symptom scores,airway remodeling indicators,serum Eotaxin levels,and incidence of adverse reactions.Results The total effective rate in the TCM-western medicine group was 92.86%,significantly higher than the 78.57%in the western medicine group(P<0.05).Both groups showed significant reductions in traditional Chinese medicine symptom scores after treatment(P<0.05),with the TCM-western medicine group showing a more pronounced decrease(P<0.05).Levels of airway remodeling indicators,including basic fibroblast growth factor(b-FGF),vascular endothelial growth factor(VEGF),and platelet-derived growth factor-BB(PDGF-BB),significantly decreased in both groups,with greater reductions in the TCM-western medicine group(P<0.05).Serum Eotaxin levels also decreased significantly in both groups,with the TCM-western medicine group having lower levels than the western medicine group(P<0.05).The overall incidence of adverse reactions was 14.29%in the western medicine group and 8.93%in the TCM-western medicine group,with no significant difference between groups(P>0.05).Conclusion Lifei Decoction combined with Budesonide/Formoterol is effective in treating children with bronchial asthma,improving traditional Chinese medicine symptoms and bronchial function,inhibiting airway remodeling,and demonstrating high safety.
作者
张松成
张孜睿卓
申广生
刘彦丽
牛银萍
ZHANG Song-cheng;ZHANG Ziruizhuo;SHEN Guang-sheng;LIU Yan-li;NIU Yin-ping(Pediatric Sixth Ward,Children′s Hospital of Nanyang Traditional Chinese Medicine Hospital,Nanyang 473000,Henan,China;不详)
出处
《广东医学》
CAS
2024年第12期1601-1605,共5页
Guangdong Medical Journal
基金
河南省中医药科学研究专项课题(2401001802)。
