摘要
目的:观察无抽搐电休克治疗(MECT)联合喹硫平在双相情感障碍(BD)躁狂发作患者中的应用效果。方法:选取2022年6月至2023年10月该院收治的78例BD躁狂发作患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各39例。对照组予以喹硫平治疗,观察组在对照组基础上联合MECT,两组均治疗4周。比较两组临床疗效,康复指标(症状缓解时间、住院期间约束次数、住院期间总约束时间)水平,治疗前后躁狂症状[Bech-Rafaelsen躁狂量表(BRMS)]评分、血清学指标[脑源性神经营养因子(BDNF)、中枢神经特异性蛋白(S100β)]水平,以及不良反应发生率。结果:观察组治疗总有效率为92.31%(36/39),高于对照组的74.36%(29/39),差异有统计学意义(P<0.05);观察组症状缓解时间、住院期间总约束时间短于对照组,住院期间约束次数少于对照组,差异均有统计学意义(P<0.05);治疗后,两组BRMS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组BDNF水平均高于治疗前,且观察组高于对照组,两组S100β水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:MECT联合喹硫平应用于BD躁狂发作患者可提高治疗总有效率,改善康复指标、血清学指标水平,降低躁狂症状评分,效果优于单纯喹硫平治疗。
Objective:To observe application effects of modified electroconvulsive therapy(MECT)combined with Quetiapine in patients with manic episodes of bipolar disorder(BD).Methods:A prospective study was conducted on 78 patients with Manic episodes of BD admitted to this hospital from June 2022 to October 2023.According to the random number table method,they were divided into control group and observation group,39 cases in each group.The control group was treated with Quetiapine,while the observation group was combined with MECT on the basis of that of the control group.Both groups were treated for 4 weeks.The clinical efficacy,the levels of rehabilitation indicators(symptom relief time,number of restraints during hospitalization,total restraint time during hospitalization),the scores of manic symptoms[Bech-Rafaelsen mania scale(BRMS)]before and after the treatment,the levels of serological indicators[brain-derived neurotrophic factor(BDNF),central nervous specific protein(S100β)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.31%(36/39),which was higher than 74.36%(29/39)of the control group,and the difference was statistically significant(P<0.05).The symptom relief time and the total restraint time during hospitalization in the observation group were shorter than those in the control group,the number of restraints during hospitalization was less than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the BRMS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of BDNF in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of S100βin the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:MECT combined with Quetiapine in patients with manic episodes of BD can improve the total effective rate of treatment,improve the levels of rehabilitation indicators and serological indicators,and reduce the score of manic symptoms.Moreover,it is superior to simple Quetiapine treatment.
作者
张娟
ZHANG Juan(Department of Psychiatric Disorders of Jian’an Hospital,Xuchang 461000 Henan,China)
出处
《中国民康医学》
2025年第1期86-88,92,共4页
Medical Journal of Chinese People’s Health
关键词
双相情感障碍
躁狂发作
喹硫平
无抽搐电休克治疗
狂躁症状
不良反应
Bipolar disorder
Manic episode
Quetiapine
Modified electroconvulsive therapy
Manic symptoms
Adverse reaction
