摘要
非小细胞肺癌是肺癌中最常见的组织学类型。近年来,随着免疫治疗的兴起,部分无法手术或靶向治疗无效的非小细胞肺癌病人获得了延长生存时间的机会。但是,由于肿瘤微环境的影响,免疫治疗的效果存在不确定性。因此,急需一种新的方式来监测肿瘤微环境的变化和免疫治疗效果。影像组学可以无创、实时和定量地分析医学图像,反映疾病更深层次的信息,已广泛应用于疾病诊断和鉴别诊断、肿瘤分期分级、疗效评价和预后预测等领域。现围绕影像组学在非小细胞肺癌肿瘤微环境及免疫治疗方面的研究进展进行综述。
Non-small cell lung cancer(NSCLC)is the most common histological type of lung cancer.In recent years,with the rise of immunotherapy,some patients with non-small cell lung cancer who are inoperable or ineffective to targeted therapy have obtained the opportunity to prolong their survival time.Meanwhile,the effect of immunotherapy is uncertain due to the influence of tumor microenvi⁃ronment.Therefore,a new approach to monitor the effects of immunotherapy and changes in tumor microenvironment is urgently need⁃ed.Radiomics can analyze medical images noninvasively,in real time and quantitatively to reflect the deeper information of disease.It has been widely used in the fields of disease diagnosis and differential diagnosis,tumor staging and grading,efficacy evaluation and prognosis prediction.This article reviews the research progress of radiomics in tumor microenvironment and immunotherapy of NSCLC.
作者
郭黎
杨朝凤
李杨
GUO Li;YANG Chaofeng;LI Yang(Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;Department of Radiology,Yuechi People's Hospital,Guang'an,Sichuan 638300,China)
出处
《安徽医药》
2025年第2期238-243,共6页
Anhui Medical and Pharmaceutical Journal
基金
南充市校科技战略合作项目(22SXQT0294)
广安市科学技术局项目(2022zdxjh18)
医学影像四川省重点实验室项目(MIKLSP2021010)
川北医学院附属医院项目(2021LC009)
岳池县人民医院横向科研项目
川北医学院医学影像学院2023年生物医学工程一流学科群建设项目(2023BME007)。
关键词
癌
非小细胞肺
影像组学
肿瘤微环境
免疫治疗
Carcinoma,non-small-cell lung
Radiomics
Tumor microenvironment
Immunotherapy
