摘要
目的:探究磁共振成像(magnetic resonance imaging,MRI)高分辨率血管壁成像联合血清elabela、肿瘤坏死因子α刺激基因-6(TSG-6)检测对颈动脉斑块稳定性的评估价值。方法:收集2022年12月至2023年12月在本院接受颈动脉内膜剥脱手术的110例患者的临床资料。根据病理诊断,患者被分为稳定组(61例)和不稳定组(49例)。采用酶联免疫吸附试验(enzyme linked im-munosorbent assay,ELISA)测定血清elabela、TSG-6水平。通过Spearman相关性分析血清ela-bela、TSG-6水平与颈动脉不稳定斑块的关系,并利用受试者操作特征(receiver operator character-istic,ROC)曲线评估血清elabela、TSG-6在诊断颈动脉斑块稳定性中的价值。结果:不稳定组血清elabela、TSG-6水平均显著高于稳定组(P<0.05),并且与颈动脉不稳定斑块的形成呈正相关(相关系数分别为0.469和0.502,P<0.05)。血清elabela和TSG-6的ROC曲线下面积(area under ROC curve,AUC)分别为0.751和0.723,表明这两种标志物在诊断颈动脉斑块稳定性方面具有一定的准确性。MRI高分辨率血管壁成像联合血清elabela、TSG-6能够更准确地诊断颈动脉斑块的稳定性。结论:MRI高分辨率血管壁成像联合血清elabela、TSG-6检测,在颈动脉粥样硬化患者斑块稳定性方面展现出临床价值,可以作为颈动脉斑块稳定性评估的有效工具。
Objective:To explore the value of high-resolution vascular wall imaging with magnetic resonance imaging(MRI)combined with serum elabela and tumor necrosis factorαstimulating gene-6(TSG-6)detection in the evaluation of carotid plaque stability.Methods:The clinical data of 110 patients who underwent carotid endarterectomy due to carotid atherosclerosis in our hospital from December 2022 to December 2023 were collected.According to the pathological diagnosis,they were separated into stable group(n=61)and unstable group(n=49).Enzyme linked immunosorbent assay(ELISA)method was applied to detect serum levels of elabela and TSG-6.Spearman correlation was applied to analyze the relationship between serum elabela and TSG-6 levels and the formation of unstable carotid artery plaques.Receiver operator characteristic(ROC)curve was applied to evaluate the diagnostic value of serum elabela and TSG-6 detection for the stability of carotid artery plaques.Four grid table was applied to analyze the value of MRI high-resolution vascular wall imaging,serum elabela,and TSG-6 index detection in diagnosing the stability of carotid artery plaques.Results:Levels of serum elabela and TSG-6 in unstable group were significantly higher than those in stable group(P<0.05),and were positively correlated with the formation of carotid unstable plaque(correlation coefficients were 0.469 and 0.502,P<0.05).The area under ROC curve(AUC)of serum elabela and TSG-6 were 0.751 and 0.723,respectively,indicating that these two markers have some accuracy in diagnosing carotid plaque stability.MRI high-resolution vascular wall imaging combined with serum elabela and TSG-6 can more accurately diagnose the stability of carotid plaque.Conclusion:MRIhigh-resolution vascular wall imaging combined with serum elabela and TSG-6 detection has demonstrated clinical value in plaque stability in patients with carotid atherosclerosis,and can be used as an effective tool to evaluate carotid plaque stability.
作者
李华莉
罗敏
姜萍
LI Huali;LUO Min;JIANG Ping(Department of Radiology,The Fourth People’s Hospital of Zigong City,Sichuan Province,Sichuan 643000,China)
出处
《影像科学与光化学》
2025年第1期95-100,107,共7页
Imaging Science and Photochemistry
