摘要
目的 研究SERPINA5基因rs938单核苷酸多态性对汉族人群脓毒症相关急性肾损伤(SA-AKI)易感性的影响。方法 选择2021年7月至2023年9月于四川省人民医院就诊的中国汉族人群863例,包括419例脓毒症患者,444例健康体检者。其中,脓毒症患者中存在急性肾损伤患者231例,无肾损伤患者188例。提取血细胞DNA,并选择性地检测SERPINA5基因SNP rs938多态性位点的基因型,分析其对中国汉族人群SA-AKI易感性影响。结果 (1)SERPINA5基因rs938单核苷酸多态性等位基因。基因型及各基因模型(显性模型、隐性模型)在中国汉族人群脓毒症及SA-AKI中未观察到显著差异。脓毒症组及与健康对照组、SA-AKI组与健康对照组组间差异均无统计学意义(P<0.05)。(2)脓毒症无肾损伤组和SA-AKI组的组间比较中,rs938的次要G等位基因与脓毒症患者发生急性肾损伤的风险降低显著相关(P<0.05);rs938的基因型及显性模型、隐性模型与中国汉族人群中脓毒症及SA-AKI的遗传易感性无关联(P<0.05)。结论 SERPINA5基因rs938多态性位点可能是与中国汉族人群发生脓毒症相关急性肾损伤的保护性因素,可成为脓毒症相关急性肾损伤新的干预靶点。
Objective To investigate the effect of rs938 single nucleotide polymorphism of SERPINA5 gene on the susceptibil-ity to sepsis associated acute kidney injury(SA-AKI)in Chinese Han population.Methods A total of 863 cases of the Chinese Han population,including 419 patients with sepsis and 444 healthy medical checkups,in our hospital from July 2021 to September 2023 were selected.Among the sepsis patients,231 had SA-AKI,and 188 did not have kidney injury.Blood cell DNA was extracted and genotypes of the rs938 polymorphic locus of the SERPINA5 gene were selectively detected.Their effects on the susceptibility to SA-AKI in Chinese Han population were analyzed.Results There were no significant differences in the rs938 single-nucleotide polymorphic al-leles,genotypes and various gene models(dominant model,recessive model and additive model)between sepsis and SA-AKI in Chi-nese Han population.No statistically significant differences were observed between the sepsis group and the healthy control group,and between the SA-AKI group and the healthy control group(P>0.05).The rs938 G allele was significantly associated with a reduced risk of AKI in patients with sepsis in comparison between the sepsis without AKI group and the AS-AKI group(P<0.05).There was no association between the genotypes and dominant model,recessive model and additive model of rs938 and the genetic susceptibility to sepsis and SA-AKI in Chinese Han population(P>0.05).Conclusions The rs938 polymorphism in SERPINA5 gene may be a pro-tective factor against SA-AKI in the Chinese Han population.It may be a new target for intervention in SA-AKI.
作者
柳逸萍
黄奕源
刘晓姝
LIU Yi-ping;HUANG Yi-yuan;LIU Xiao-shu(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China;Department of Respiratory and Critical Care,Sichuan Academy of Medical Sciences·Sichuan Provincial People's Hospital(Affiliated Hospital of University of Electronic Science and Technology of China),Chengdu 610072,China)
出处
《实用医院临床杂志》
2025年第1期68-71,共4页
Practical Journal of Clinical Medicine
基金
四川省科技厅重点研发计划科研资助项目(编号:2022YFS0265)。
