摘要
目的:探讨复方乌贝方联合泮托拉唑治疗脾胃湿热型慢性浅表性胃炎(CSG)的疗效及对胃肠道黏膜功能的影响。方法:选取2021年7月至2023年7月在保定市第二医院确诊的脾胃湿热型CSG患者98例,采用随机数字表法分为对照组(49例)和治疗组(49例)。治疗组患者采用复方乌贝方联合泮托拉唑治疗,对照组患者采用泮托拉唑治疗。比较两组CSG患者的临床疗效,比较治疗前后两组CSG患者的中医证候积分,使用胃镜检查并比较两组CSG患者治疗前后的病灶情况,测定血清生长抑素(SS)、表皮生长因子(EGF)和胃泌素(GAS)水平。观察并比较两组患者在治疗过程中的不良反应。结果:治疗后,治疗组患者的临床总有效率为95.92%(47/49),较对照组(83.67%,41/49)更高,差异有统计学意义(P<0.05)。治疗后,两组CSG患者的舌苔黄腻、胸闷、便溏及胃胀胃痛积分降低,且治疗组患者上述积分低于对照组,差异均有统计学意义(P<0.05)。胃镜检查结果显示,治疗后,两组中胃液反流、充血糜烂、黏液增多及水肿患者均减少,治疗组中胃液反流、充血糜烂、黏液增多及水肿患者占比低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组CSG患者血清EGF、SS水平升高,GAS水平降低,且治疗组血清EGF、SS水平高于对照组,血清GAS水平低于对照组,差异均有统计学意义(P<0.05)。治疗期间,治疗组、对照组患者不良反应发生率[2.04%(1/49)vs.6.12%(3/49)]比较,差异无统计学意义(P>0.05)。结论:复方乌贝方联合泮托拉唑治疗CSG疗效显著,能够修复患者的胃肠道黏膜功能,改善临床相关症状。
OBJECTIVE:To probe into the efficacy of compound Wubei formula combined with pantoprazole in the treatment of chronic superficial gastritis(CSG)of spleen-stomach damp-heat type and its effects on gastrointestinal mucosal function.METHODS:A total of 98 patients with CSG of spleen-stomach damp-heat type admitted into the No.2 Hospital of Baoding from Jul.2021 to Jul.2023 were selected to be divided into the control group(49 cases)and treatment group(49 cases)via random number table method.The treatment group was given compound Wubei formula combined with pantoprazole,the control group received pantoprazole.Clinical efficacy were compared between two groups,traditional Chinese medicine syndrome integral were compared between two groups before and after treatment,gastroscopy was performed to compared the lesion status between two groups before and after treatment,the serum somatostatin(SS),epidermal growth factor(EGF)and gastrin(GAS)levels were detected.Adverse drug reactions of two groups during treatment were observed and compared.RESULTS:The clinical total effective rate of the treatment group was 95.92%(47/49),higher than 83.67%(41/49)of the control group,with statistically significant difference(P<0.05).After treatment,the scores of yellow and greasy tongue coating,chest tightness,loose stools,stomach bloating and pain of both groups decreased,and the above scores in the treatment group were lower than those in the control group,with statistically significant differences(P<0.05).Results of gastroscopy showed that after treatment,the number of CSG patients with gastric reflux,congestion and erosion,increased mucus and edema of both groups decreased,the proportion of patients with gastric reflux,congestion and erosion,increased mucus and edema in the treatment group was lower than that in the control group,with statistically significant differences(P<0.05).After treatment,the serum EGF and SS levels increased and the GAS levels decreased in both groups,the serum EGF and SS levels were higher,the GAS level was lower in the observation group than those in the control group,with statistically significant differences(P<0.05).During treatment,the incidences of adverse drug reactions between treatment group and control group[2.04%(1/49)vs.6.12%(3/49)]were not statistically significant(P>0.05).CONCLUSIONS:The efficacy of compound Wubei formula combined with pantoprazole in the treatment of CSG is remarkable,which can repair the gastrointestinal mucosal function and improve the clinical symptoms.
作者
梁硕
宋立明
马建超
冯云
LIANG Shuo;SONG Liming;MA Jianchao;FENG Yun(Dept.of Cardiovascular Medicine,the No.2 Hospital of Baoding,Hebei Baoding 017000,China;Dept.of Traditional Chinese Medicine,the Sixth People’s Hospital of Hengshui,Hebei Hengshui 053200,China;Dept.of Emergency,the Sixth People’s Hospital of Hengshui,Hebei Hengshui 053200,China;Dept.of Rheumatology and Immunology&Nephrology,the No.2 Hospital of Baoding,Hebei Baoding 017000,China)
出处
《中国医院用药评价与分析》
2025年第1期69-71,75,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
河北省中医药管理局2023年度中医药类科学研究课题(No.2023466)。
关键词
复方乌贝方
泮托拉唑
慢性浅表性胃炎
疗效
胃肠道黏膜功能
Compound Wubei formula
Pantoprazole
Chronic superficial gastritis
Efficacy
Gastrointestinal mucosal function
