摘要
目的探究血清上皮细胞膜结合黏液素1(MUC1)、6-酮-前列腺素F1α(6-Keto-PGF1α)水平与急性消化道出血患者输血治疗预后情况。方法选择2021年9月至2023年9月就诊于张家口市第一医院输血科行输血治疗的急性消化道出血患者97例,根据预后将患者分为不良组(42例)与良好组(55例),采用酶联免疫法分析2组血清MUC1,6-Keto-PGF1α水平,Pearson分析不良组血清MUC1和6-Keto-PGF1α水平的相关性。结果良好组血清MUC1和6-Keto-PGF1α水平显著低于不良组,差异有统计学意义(P<0.05);不良组血清MUC1和6-Keto-PGF1α水平呈正相关(r=0.366、P=0.017);良好组输血量少于不良组,消化道溃疡史低于不良组(P<0.05)。结论急性消化道出血输血治疗后,预后不良患者血清MUC1,6-Keto-PGF1α水平升高,未来可能通过监测血清MUC1,6-Keto-PGF1α水平为急性消化道出血输血治疗后预后情况提供参考。
Objective To investigate the relationship between serum mucin 1(MUC1),6⁃keto⁃prostaglandin F1α(6⁃Keto⁃PGF1α)levels and the prognosis of transfusion therapy in patients with acute gastrointestinal bleeding.Methods From September 2021 to September 2023,97 patients with acute gastrointestinal bleeding who received transfusion therapy at our hospital were gath⁃ered and assigned into adverse group and good group according to prognosis.Enzyme linked immunosorbent assay was applied to an⁃alyze the levels of serum MUC1 and 6⁃Keto⁃PGF1α.Pearson method was applied to analyze the correlation between serum MUC1 and 6⁃Keto⁃PGF1αlevels in the adverse group.Results The levels of serum MUC1 and 6⁃Keto⁃PGF1αin the good group were prominently lower than those in the adverse group(P<0.05).The levels of serum MUC1 and 6⁃Keto⁃PGF1αin the adverse group were positively correlated(r=0.366,P=0.017).The transfusion volume in the good group was less than that in the adverse group,and the proportion of history of digestive ulcers was lower than that in the adverse group(P<0.05).Conclusion Serum MUC1,6⁃Keto⁃PGF1αlevels are elevated in patients with poor prognosis after transfusion therapy for acute gastrointestinal hemor⁃rhage,and in the future it may be possible to provide a reference for the prognostic situation after transfusion therapy for acute gas⁃trointestinal hemorrhage by monitoring serum MUC1,6⁃Keto⁃PGF1αlevels.
作者
张盟盟
张亚平
梁艳霞
秦欢
ZHANG Mengmeng;ZHANG Yaping;LIANG Yanxia;QIN Huan(Department of Blood Transfusion,Zhangjiakou First Hospital,Zhangjiakou,Heibei 075000,China;Department of Blood Transfusion,The Second Hospital of Hebei Medical University,Shijiazhuang,050000,China;Department of Blood Transfusion,Dingzhou People's Hospital,Dingzhou,Hebei 073000,China)
出处
《转化医学杂志》
2024年第7期1027-1030,共4页
Translational Medicine Journal
基金
河北省医学科学研究课题计划项目(20200896)。
