摘要
目的调查贵州黔西南州人民医院就诊患者维生素D缺乏情况并分析其影响因素,为制定有效的公共卫生策略提供科学依据。方法回顾性收集于黔西南州人民医院就诊期间检测血清25(OH)D水平的患者105296例为调查对象,采用电化学发光法检测血清25(OH)D,参照《维生素D及其类似物的临床应用共识》将调查对象分为维生素D充足者、维生素D不足者及维生素D缺乏者。收集调查对象性别、年龄、住院情况、就诊季节等资料,比较调查对象血清25(OH)D水平及维生素D缺乏情况,采用二元Logistic回归分析确定调查对象维生素D缺乏的影响因素。结果105296例调查对象血清25(OH)D水平为26.68(19.46,37.02)ng/mL,其中维生素D缺乏28298例(26.87%),维生素不足34769例(33.02%)。男性调查对象血清25(OH)D水平高于女性,维生素D缺乏率低于女性(P<0.05)。门诊患者血清25(OH)D水平高于住院患者,维生素D缺乏率低于住院患者(P均<0.05)。随着年龄增长,调查对象血清25(OH)D水平逐渐下降、维生素D缺乏率逐渐上升,其中0~6岁调查对象血清25(OH)D水平最高、维生素D缺乏率最低,≥70岁调查对象血清25(OH)D水平最低、维生素D缺乏率最高(P均<0.01)。调查对象血清25(OH)D水平夏季>秋季>春季>冬季,维生素D缺乏率冬季>春季>秋季>夏季(P均<0.05)。二元Logistic回归分析结果显示,性别、年龄、是否住院、就诊季节均为调查对象维生素D缺乏的影响因素(P均<0.05)。结论黔西南州人民医院就诊患者普遍存在维生素D不足和缺乏情况,性别、年龄、是否住院和就诊季节均为患者维生素D缺乏的影响因素。
Objective To investigate the prevalence of vitamin D deficiency among patients at Qianxinan People´s Hospital in Guizhou,coupled with an analysis of its associated influencing factors,which can provide a scientific foundation for the formulation of effective public health strategies.Methods This study retrospectively collected data from 105,296 patients who underwent serum 25-hydroxyvitamin D[25(OH)D]level testing during their visits to Qianxinan People´s Hospital as the study subjects.The serum 25(OH)D levels were detected by electrochemiluminescence method,and based on the"Consensus on the Clinical Application of Vitamin D and Its Analogues",the study subjects were categorized into three groups:individuals with sufficient vitamin D,those with vitamin D insufficiency,and those with vitamin D deficiency.Data on gender,age,hospitalization status,and season of visit were collected.The serum 25(OH)D levels and vitamin D deficiency status of the subjects were compared.Binary Logistic regression analysis was performed to identify the factors influencing vitamin D deficiency among the study participants.Results The serum 25(OH)D level of 105,296 study subjects was 26.68(19.46,37.02)ng/mL;among them,28,298 cases(26.87%)had vitamin D deficiency,and 34,769 cases(33.02%)had vitamin D insufficiency.The serum 25(OH)D levels in male subjects were higher than those in female subjects,and the vitamin D deficiency rate was lower in males than in females(all P<0.05).Outpatients had a higher serum 25(OH)D level and a lower vitamin D deficiency rate compared with inpatients(both P<0.05).The serum 25(OH)D level decreased,and the vitamin D deficiency rate increased with increasing age.The highest 25(OH)D level and lowest deficiency rate were found in the 0–6 years group,while the lowest 25(OH)D level and highest deficiency rate were observed in the≥70 years group(both P<0.01).The 25(OH)D levels were lower in hospitalized patients in comparison with the outpatient ones.The serum 25(OH)D level was the highest in summer,followed by autumn,spring,and winter.The vitamin D deficiency rate was the highest in winter,followed by spring,autumn,and summer(all P<0.05).The results of the binary Logistic regression analysis indicated that gender,age,hospitalization status,and season were all significant factors influencing vitamin D deficiency in the study subjects.Conclusions Vitamin D insufficiency and deficiency are prevalent among patients visiting Qianxinan People´s Hospital.Gender,age,hospitalization status,and season are all factors that influence vitamin D deficiency.
作者
吴林丽
鲍林春
李万林
华东
冯宁
WU Linli;BAO Linchun;LI Wanlin;HUA Dong;FENG Ning(Laboratory Medicine,People's Hospital of Qianxinan Prefecture,Xingyi 562400,China)
出处
《山东医药》
2025年第1期81-85,共5页
Shandong Medical Journal
基金
贵州省卫生健康委科学技术基金项目(Gzwkj2022-279)
贵州省黔西南州科学技术局基金项目(2023-3-36)。
