摘要
目的基于定量CT(QCT)分析正常体质量指数(BMI)人群内脏脂肪面积(VFA)与甘油三酯-葡萄糖(TyG)指数的相关性。方法回顾性分析1358名接受QCT体质成分测定且BMI正常的健康成年体检者,根据QCT所测VFA将其分为正常内脏脂肪组(正常组,VFA<100 cm^(2),n=509)、轻度内脏脂肪蓄积组(轻度组,100 cm^(2)≤VFA<150 cm^(2),n=431)及重度内脏脂肪蓄积组(重度组,VFA≥150 cm^(2),n=418)。分别以Pearson或Spearman相关分析观察20~40、41~60及61~90岁BMI正常男、女性一般资料、体质成分与TyG指数的相关性;采用多元线性回归分析筛选BMI正常人群TyG指数的独立影响因素。结果各年龄段BMI正常男性低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、谷丙转氨酶(GPT)、VFA及皮下脂肪面积(SFA)与TyG指数呈弱-低度正相关(r=0.143~0.459,P均<0.05),高密度脂蛋白胆固醇(HDL-C)与TyG指数呈弱-低度负相关(r=-0.410~-0.222,P均<0.05)。各年龄段BMI正常女性LDL-C、VFA及SFA与TyG指数呈弱-低度正相关(r=0.206~0.495,P均<0.05)。谷丙转氨酶(GPT)、TC、VFA及肝脏脂肪含量(LFC)均为BMI正常人群TyG指数的独立危险因素(P均<0.05),HDL-C为其独立保护因素(P<0.05)。结论BMI正常人群VFA与TyG指数呈正相关;基于QCT测量腹部体质成分联合血脂指标对预测腹型肥胖人群胰岛素抵抗及相关代谢性疾病具有一定潜力。
Objective To explore the correlation between visceral fat area(VFA)and triglyceride-glucose(TyG)index in people with normal body mass index(BMI)based on quantitative CT(QCT).Methods Totally 1358 healthy adults with normal BMI who underwent QCT body composition measurement were retrospectively enrolled and divided into normal visceral fat group(normal group,VFA<100 cm^(2),n=509),mild visceral fat accumulation group(mild group,100 cm^(2)≤VFA<150 cm^(2),n=431)and severe visceral fat accumulation group(severe group,VFA≥150 cm^(2),n=418)according to VFA measured with QCT.Pearson and Spearman correlation analysis were performed to observe correlations of TyG index with general data and body composition in 20—40,41—60,61—90 years old men and women with normal BMI,respectively.Multiple linear regression analysis was performed to screen the independent impact factors of TyG index in normal BMI people.Results Low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),glutamic-pyruvic transaminase(GPT),VFA and subcutaneous fat area(SFA)of men with normal BMI at different age stages were weakly-lowly positively correlated with TyG index(r=0.143—0.459,all P<0.05),while high-density lipoprotein cholesterol(HDL-C)were weakly-lowly negatively correlated with TyG index(r=-0.410—-0.222,all P<0.05).LDL-C,VFA and SFA of women with normal BMI at different age stages were weakly-lowly positively correlated with TyG index(r=0.206—0.495,all P<0.05).GPT,TC,VFA and liver fat content(LFC)were all independent risk factors,while HDL-C was independent protective factor for TyG index in people with normal BMI(all P<0.05).Conclusion VFA was positively correlated with TyG index in people with normal BMI.Measurement of abdominal body composition based on QCT combined with lipid indexes had certain potential for predicting insulin resistance and relative metabolic diseases in abdominal obese people.
作者
李鑫
周阳
邹智
周菁
张潇琳
屈敏
李昊
李永丽
LI Xin;ZHOU Yang;ZOU Zhi;ZHOU Jing;ZHANG Xiaolin;QU Min;LI Hao;LI Yongli(Department of Medical Imaging,Henan University People's Hospital,Zhengzhou 450003,China;Department of Medical Imaging,Zhengzhou University People's Hospital,Zhengzhou 450003,China;Department of Health Management,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Health Management,Fuwai Central China Cardiovascular Hospital,Zhengzhou 450003,China)
出处
《中国医学影像技术》
北大核心
2025年第1期104-108,共5页
Chinese Journal of Medical Imaging Technology
基金
河南省科技发展计划(242102311121)。
