摘要
目的探讨含蜈蚣的中西医治疗方案对间质性肺病(interstitial lung disease,ILD)患者临床症状体征评分、CT评分、肺功能的影响及其安全性。方法选取2021年1月至2022年6月于我院治疗的102例ILD患者为研究对象,分为对照组及联合组,每组51例。对照组采用规范西医治疗,联合组在对照组的基础上联合采用含蜈蚣的规范中医治疗,比较两组疗效及治疗后临床症状体征评分、CT评分、用力肺活量(forced vital capacity,FVC)及一氧化碳弥散量(carbon monoxide diffusing capacity,DLCO)。结果联合组总有效率高于对照组(P<0.05)。治疗3个月后,对照组CT评分为(9.25±2.42)分,联合组为(7.26±1.48)分,组间差异有统计学意义(P<0.05)。联合组咳嗽、气喘及乏力等临床症状评分低于对照组(P<0.05);联合组FVC、DLCO高于对照组(P<0.05)。治疗期间,联合组口腔感染、心律失常及声音嘶哑等不良反应发生率为11.76%,与对照组的9.80%相比,差异无统计学意义(P>0.05)。结论含蜈蚣的中西医治疗方案能够提升ILD患者的治疗效果,减轻咳嗽、乏力等临床症状体征,改善肺功能,且安全性高。
Objective To investigate the effect and safety of Chinese and western medicine regimen containing centipede on clinical symptom and sign score,CT score and lung function in patients with interstitial lung disease(ILD).Methods A total of 102 patients with ILD who treated in our hospital from January 2021 to June 2022 were selected as the research objects and divided into the control group and the combined group,with 51 cases in each group.The control group was treated with standard western medicine,and the combined group was treated with standard traditional Chinese medicine containing centipede on the basis of the control group.The curative effect,clinical symptoms and signs scores,CT scores,and forced vital capacity(FVC)and carbon monoxide diffusing capacity(DLCO)after treatment were compared between the two groups.Results The total effective rate of the combined group was higher than that of the control group(P<0.05).After 3 months of treatment,the CT score of the control group was(9.25±2.42)points,and the combined group was(7.26±1.48)points,the difference between the two groups was statistically significant(P<0.05).The scores of clinical symptoms such as cough,asthma and fatigue in the combined group were lower than those in the control group(P<0.05).After 3 months of treatment,the FVC and DLCO of the combined group were higher than those of the control group(P<0.05).During treatment,the incidence of oral infection,arrhythmia,hoarseness and other adverse reactions in the combined group was 11.76%,which was not significantly different from 9.80%in the control group(P>0.05).Conclusion The Chinese and western medicine treatment regimen containing centipede can improve the treatment effect of ILD patients,reduce clinical symptoms and signs such as cough and fatigue,improve lung function,and has high safety.
作者
韩秀娟
李艳辉
石朝民
HAN Xiujuan;LI Yanhui;SHI Chaomin(Department of Spleen and Stomach Diseases and Pulmonary Diseases,Zibo Hospital of Traditional Chinese Medicine,Zibo 255399,Shandong Province,China)
出处
《世界临床药物》
2024年第12期1252-1257,共6页
World Clinical Drug
基金
山东省中医药科技项目计划(2021Q052)。
关键词
蜈蚣
中西医治疗
间质性肺病
临床症状体征评分
CT评分
肺功能
安全性
scolopendra
treatment of Chinese and western medicine
interstitial lung disease
clinical symptom and sign score
CT score
pulmonary function
safety
