摘要
目的:探讨硫酸镁联合生长抑素治疗对急性胰腺炎患者血清酶类指标、肠道屏障功能指标的影响。方法:选取2022年1月—2024年1月本院诊治的96例急性胰腺炎患者,采用随机数字表法将患者分为A组(n=48,硫酸镁联合生长抑素治疗2周)和B组(n=48,生长抑素治疗2周),比较两组临床效果、血清酶类指标、肠道屏障功能指标、炎症相关指标,记录两组治疗期间不良反应发生情况。结果:A组腹痛消失、腹胀消失、恢复排气、腹部压痛消失和平均住院时间短于B组,差异有统计学意义(P<0.05);两组治疗后淀粉酶(AMS)和脂肪酶(LPS)水平较治疗前降低,氧磷酶1(PON1)水平较治疗前升高,且A组优于B组,差异有统计学意义(P<0.05);两组治疗后内毒素(PE)、D-乳酸(DLA)和人二胺氧化酶(DAO)水平均较治疗前降低,且A组低于B组,差异有统计学意义(P<0.05);两组治疗后微管关联蛋白1轻链3(MAP1-LC3)、可溶性髓系细胞触发受体-1(s TREM-1)、P物质(SP)水平均较治疗前降低,且A组低于B组,差异有统计学意义(P<0.05);A组不良反应发生率与B组比较,差异无统计学意义(P>0.05)。结论:硫酸镁联合生长抑素治疗急性胰腺炎患者具有较好疗效,可以改善血清酶类指标和炎症水平,增强患者肠道屏障功能。
Objective:To investigate the effect of magnesium sulfate combined with somatostatin on serum enzyme indexes and intestinal barrier function indexes in patients with acute pancreatitis.Methods:A total of 96 patients with acute pancreatitis diagnosed and treated in our hospital from January 2022 to January 2024 were selected.The patients were divided into group A(n=48,magnesium sulfate combined with somatostatin for 2 weeks)and group B(n=48,somatostatin for 2 weeks)by random number table method.The clinical effects,serum enzyme indexes,intestinal barrier function indexes and inflammation related indexes of the two groups were compared,and the occurrence of adverse reactions during the treatment of the two groups was recorded.Results:The disappearance of abdominal pain,abdominal distension,recovery of exhaust,disappearance of abdominal tenderness and average hospitalization time in group A were shorter than those in group B,and the differences were statistically significant(P<0.05).After treatment,the levels of amylase(AMS)and lipase(LPS)in the two groups were lower than those before treatment,and the level of oxygen phosphorus enzyme 1(PON1)was higher than that before treatment,and group A was better than group B,the differences were statistically significant(P<0.05).After treatment,the levels of endotoxin(PE),D-lactic acid(DLA)and human diamine oxidase(DAO)in the two groups were lower than those before treatment,and those in group A were lower than those in group B,the differences were statistically significant(P<0.05).After treatment,the levels of microtubule-associated protein 1 light chain 3(MAP1-LC3),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and substance P(SP)in the two groups were lower than those before treatment,and those in group A were lower than those in group B,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between group A and group B(P>0.05).Conclusion:Magnesium sulfate combined with somatostatin has a good effect in the treatment of patients with acute pancreatitis,which can improve serum enzyme indexes and inflammation levels,and enhance the intestinal barrier function of patients.
作者
陈杨波
林施瑞
CHEN Yangbo;LIN Shirui(Department of Gastroenterology,Minhou General Hospital/Minhou Hospital,Fuzhou 350100,Fujian,China)
出处
《中国药物滥用防治杂志》
2024年第12期2262-2263,2268,共3页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
急性胰腺炎
硫酸镁
生长抑素
肠道屏障功能
Acute pancreatitis
Magnesium sulfate
Somatostatin
Intestinal barrier function
