摘要
目的通过分析人类免疫缺陷病毒(human immunodeficiency virus,HIV)血清学单试剂反应性献血者归队检测结果,探讨现有归队策略设置的合理性及实际效果。方法选取温州地区2023年1月至12月HIV血清学单试剂反应性献血者为研究对象,经温州市疾病预防控制中心(Center for Disease Control and Prevention,CDC)确认检测及归队检测确认是否可以归队,通过献血者基本资料与屏蔽时HIV血清学试验S/CO值分析允许归队率的差异。结果HIV血清学单试剂反应性献血者374人,经CDC确认检测,HIV抗体不确定55人,符合归队条件者319人,主动申请归队84人。78人经归队自检、归队检测均无反应性,允许归队。4人归队自检HIV血清学反应性,1人归队检测HIV核酸检测(nucleic acid testing,NAT)试验反应性,永久屏蔽;1人归队检测抗HIV化学发光免疫测定试验反应性,HIV NAT试验无反应性,继续屏蔽参加下一轮归队。不同年龄、血型及献血次数献血者的允许归队率比较差异均有统计学意义(P<0.05)。屏蔽时不同S/CO值的献血者允许归队率比较差异无统计学意义(χ^(2)=1.898,P=0.168)。结论合理的归队流程可有效减少献血者流失、保障临床用血安全。
Objective Based on the analysis of the results of retesting of blood donors with human immunodeficiency virus(HIV)serological single-reagent reactivity,the rationality and practical effect of the existing retesting strategy were discussed.Methods HIV serological single-reagent reactivity blood donors in Wenzhou from January to December 2023 were selected as the study objects,and were confirmed by Wenzhou Center for Disease Control and Prevention(CDC)and returning test to confirm whether they could be returnee.Differences in return rates were analyzed by the basic data of blood donors and the S/CO value of HIV serological test during screening.Results Among the 374 HIV serological single-reagent reactivity blood donors,55 were confirmed by CDC with uncertain HIV antibodies,319 met the criteria for return,and 84 actively applied for return.78 showed no reactivity through self-test and return test and were allowed to return to the team.Four showed HIV serological reactivity,one showed HIV nucleic acid testing(NAT)test reactivity,permanent shielding.One showed the reactivity of anti-HIV chemiluminescence immunoassay test,and the HIV NAT test was noreactivity,and continued to be screened to participate in the next round of return.There were statistically significant differences in the permissible return rate of blood donors with different ages,blood types and blood donation times(P<0.05).There was no significant difference in the allowed return rate of blood donors with different S/CO values during screening(χ^(2)=1.898,P=0.168).Conclusion Reasonable return procedures can effectively reduce the loss of blood donors and ensure the safety of blood for clinical use.
作者
杨杰
张锋
陈晓燕
吴娅娅
林杨杨
朱慧琼
YANG Jie;ZHANG Feng;CHEN Xiaoyan;WU Yaya;LIN Yangyang;ZHU Huiqiong(Department of Quality Control,Wenzhou Central Blood Station,Wenzhou Key Laboratory of Blood Transfusion Medicine,Wenzhou 325000,Zhejiang,China)
出处
《中国现代医生》
2025年第1期14-17,共4页
China Modern Doctor
基金
浙江省温州市基础性医疗卫生科技项目(Y2023779)。
关键词
人类免疫缺陷病毒
单试剂反应性
献血者
血液安全
Human immunodeficiency virus
Single-reagent reactivity
Blood donor
Blood safety
