摘要
目的:观察肺力咳合剂联合氨溴特罗口服溶液治疗肺炎支原体肺炎(MPP)患儿的效果。方法:选取2023年6月至2024年6月该院收治的62例MPP患儿进行前瞻性研究,按随机数字表法将其分为对照组与观察组各31例。对照组予以氨溴特罗口服溶液治疗,观察组在对照组基础上联合肺力咳合剂治疗,比较两组临床症状消失时间,治疗前后肺功能指标[呼气峰值流速(PEF)、用力肺活量(FVC)、最大呼气中段流量(MMF)]、炎性因子[C反应蛋白(CRP)、降钙素原(PCT)]、免疫功能指标[免疫球蛋白(Ig)A、IgM、IgG]水平,以及不良反应发生率。结果:观察组咳痰、咳嗽、肺啰音、发热等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组PEF、FVC、MMF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组CRP、PCT水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组IgA、IgM、IgG水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肺力咳合剂联合氨溴特罗口服溶液治疗MPP患儿可提高肺功能指标和免疫功能指标水平,缩短临床症状消失时间,以及降低炎性因子水平的效果优于单纯氨溴特罗口服溶液治疗。
Objective:To observe effects of Feilike mixture combined with Ambroxol hydrochloride and Clenbuterol hydrochloride oral solution in treatment of children with mycoplasma pneumoniae pneumonia(MPP).Methods:A prospective study was conducted on 62 children with MPP admitted to the hospital from June 2023 to June 2024.According to the random number table method,they were divided into control group and observation group,31 cases in each group.The control group was treated with Ambroxol hydrochloride and Clenbuterol hydrochloride oral solution,while the observation group was treated with Feilike mixture on the basis of that of the control group.The disappearance time of clinical symptoms,the levels of pulmonary function indexes[peak expiratory flow(PEF),forced vital capacity(FVC),maximum mid-expiratory flow(MMF)],inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT)],and immune function indexes[immunoglobulin(Ig)A,IgM,IgG]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The disappearance time of clinical symptoms such as expectoration,cough,pulmonary rales and fever in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PEF,FVC and MMF in the two groups were higher than those before the treatment,and those in the observation group were higher than the control group,the differences were statistically significant(P<0.05).The levels of CRP and PCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of IgA,IgM and IgG in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Feilike mixture combined with Ambroxol hydrochloride and Clenbuterol hydrochloride oral solution in the treatment of the children with MPP can improve the levels of pulmonary function indexes and immune function indexes,shorten the disappearance time of clinical symptoms,and reduce the levels of inflammatory factors.Moreover,it is superior to simple Ambroxol hydrochloride and Clenbuterol hydrochloride oral solution treatment.
作者
彭静君
PENG Jingjun(Department of Pediatrics of Renhuai New-Chaoyang Hospital,Renhuai 564599 Guizhou,China)
出处
《中国民康医学》
2025年第3期104-106,131,共4页
Medical Journal of Chinese People’s Health
关键词
肺炎支原体肺炎
肺力咳合剂
氨溴特罗口服溶液
炎性因子
免疫功能
临床症状
Mycoplasma pneumoniae pneumonia
Feilike mixture
Ambroxol hydrochloride and Clenbuterol hydrochloride oral solution
Inflammatory factor
Immune function
Clinical symptom
