摘要
目的研究小剂量阿司匹林和低分子肝素钠结合用药对子痫前期患者的临床意义。方法研究对象选择临沂市中心医院2023年6月至2024年6月收治的子痫前期患者,共100例。以治疗方案的不同分成2个小组,各50例。对照组在基础卧床休息、降压、解痉治疗的基础上口服小剂量阿司匹林用药,观察组在对照组方案上结合低分子肝素钠皮下注射。观察临床效果、血压(收缩压、舒张压)与24 h尿蛋白定量、凝血指标[凝血酶原时间(PT)、凝血活酶时间(APTT)、纤维蛋白原(FIB)和血小板计数(PLT)]与不良母婴结局的发生情况。结果观察组的临床治疗总有效率高于对照组,血压、24 h尿蛋白定量以及不良母婴结局发生率均低于对照组(均P<0.05);治疗后,与对照组比较,观察组FIB、PLT水平更低,PT、APTT水平更高(均P<0.05)。结论对子痫前期患者在小剂量阿司匹林的基础上结合低分子肝素钠方案,在改善患者的血压与尿蛋白指标、凝血功能以及母婴结局方面均具有优势。
Objective To study the clinical significance of the combination of low-dose aspirin and low molecular weight heparin sodium in patients with preeclampsia.Methods A total of 100 cases of preeclampsia patients admitted to Linyi Central Hospital from June 2023 to June 2024 were selected for the study.They were divided into 2 groups of 50 cases each by the difference of treatment protocols.The control group was administered oral low-dose aspirin on the basis of basic bed rest,antihypertensive and antispasmodic treatment,and the observation group was combined with subcutaneous injection of low molecular heparin sodium on the basis of the control group’s protocol.Clinical outcomes,blood pressure(systolic blood pressure,diastolic blood pressure)and 24 h urine protein quantification,coagulation indexes[prothrombin time(PT),activated prothrombin time(APTT),fibrinogen(FIB)and platelet count(PLT)]and the occurrence of adverse maternal and infant outcomes were observed.Results The total effective rate of clinical treatment of the observation group was higher than that of the control group,and the incidence of blood pressure,24-hour urine protein quantification and adverse maternal and infant outcomes were lower than that of the control group(all P<0.05).After treatment,compared with the control group,the observation group had lower levels of FIB and PLT,and higher levels of PT and APTT(all P<0.05).Conclusions For patients with preeclampsia,low-dose aspirin combined with low-molecular-weight heparin sodium regimen has significant advantages in improving blood pressure,urine protein indexes,coagulation function,and maternal and infant outcomes.
作者
赵苏
相李平
ZHAO Su;XIANG Liping(Department of Obstetrics,Linyi Central Hospital,Linyi,Shandong 276400,China)
出处
《中国医药指南》
2025年第4期39-41,共3页
Guide of China Medicine
关键词
子痫前期
小剂量阿司匹林
低分子肝素钠
临床效果
母婴结局
Preeclampsia
Low-dose aspirin
Low molecular weight heparin sodium
Clinical effects
Maternal and infant outcomes
