摘要
狼疮性肾炎(lupus nephritis,LN)是系统性红斑狼疮(systemic lupus erythematosus,SLE)常见且严重的并发症。LN的临床病程通常以缓解期和加重期交替为特征。LN的发作可导致肾功能恶化,需要及时诊断和治疗。活化的白细胞黏附分子(activated leukocyte cell adhedsion molecule,ALCAM)的存在和变化可能与LN的发展以及活性有关。尿活化的白细胞黏附分子(urinary activated leukocyte cell adhesion molecule,uALCAM)有望作为评估SLE患者LN活性的非侵入性标志物。uALCAM有助于早期诊断,疾病活动的指示和预测疾病复发。ALCAM在多种细胞中表达,发挥不同生物学效应,包括调节细胞分化、增殖和迁移,在各种恶性肿瘤中也有病理表达,具有致癌特性。本文将围绕ALCAM在LN发生和进展中的作用的现有研究,及ALCAM作为新的诊断标志物和治疗靶点的潜在作用进行综述。
Lupus nephritis(LN)is a common and serious complication of systemic lupus erythematosus(SLE).The clinical course of LN is usually characterized by alternating phases of remission and exacerbation.The onset of LN can lead to deterioration of renal function and requires prompt diagnosis and treatment.Some studies have suggested that the presence and changes of activated leukocyte cell adhesion molecule(ALCAM)may be related to the development of LN as well as LN activity.Urinary activated leukocyte cell adhesion molecule(uALCAM)is promising as a non-invasive marker for evaluating LN activity in SLE patients.Determination of uALCAM levels is helpful in early diagnosis,indication of disease activity and prediction of disease recurrence.ALCAM is expressed in a variety of cells and exerts different biological effects,including regulating cell differentiation,proliferation and migration.It is also pathologically expressed in various malignant tumors and has carcinogenic properties.This review will review the existing research on the role of ALCAM in the genesis and progression of LN,and the potential role of ALCAM as a new diagnostic marker and therapeutic target.
作者
翁克霞
李冰
Weng Kexia;Li Bing(Nephrology Department,the Second Affiliated Hospital Clinical College of Hainan Medical University,Haikou 571199,China;Nephroglogy of Institute,the Second Affiliated Hospital,Hainan Medical University/Hainan Clinical Research Center for Urinary System Diseases,Haikou 570216,China;National Health Commission of China,Key Laboratory of Tropical Disease Control,School of Tropical Medicine,Hainan Medical University,Haikou 571199,China)
出处
《首都医科大学学报》
北大核心
2025年第1期150-153,共4页
Journal of Capital Medical University
基金
国家自然科学基金项目(82370697)
海南省临床医学研究中心项目(LCYX202409)
国家卫生健康委员会热带病防治重点实验室开放基金项目(2020-PT310-009)。
关键词
狼疮肾炎
活化的白细胞黏附分子
生物标志物
治疗靶点
lupus nephritis
activated leukocyte cell adhesion molecule
biomarkers
therapeutic targets
