摘要
目的 探讨术前血清sVEGF-C、sICAM-1对胆囊癌根治性切除患者预后的预测价值。方法 选取行胆囊癌根治性切除术患者76例,采用酶联免疫吸附法检测血清sVEGF-C、sICAM-1水平,统计患者预后情况,比较两组术前血清sVEGF-C、sICAM-1水平,单因素分析及多因素Logistic回归分析影响胆囊癌根治性切除术患者预后的因素,ROC曲线分析血清sVEGF-C、sICAM-1水平预测胆囊癌根治性切除术患者预后不良的效能。结果 随访1年,无失访,预后不良占38.16%(29/76)。依据预后情况分组,即预后良好组和预后不良组。预后不良组术前血清sVEGF-C、sICAM-1水平高于预后良好组,P<0.05;不同T分期、N分期、M分期、临床病理分期的胆囊癌根治性切除术患者血清sVEGF-C、sICAM-1水平存在显著差异(P<0.05);T分期、N分期是胆囊癌根治性切除术患者术后预后不良的保护因素(P<0.05),M分期、临床病理分期、血清sVEGF-C、sICAM-1是胆囊癌根治性切除术患者术后预后不良的危险因素(P<0.05);血清sVEGF-C、sICAM-1单独及联合应用的AUC分别为0.718、0.683、0.841。结论 术前血清sVEGF-C、sICAM-1水平升高与胆囊癌根治性切除术患者术后预后不良有关,术前血清sVEGF-C、sICAM-1联合检测预测胆囊癌根治性切除术患者预后不良的价值较高。
Objective To investigate the predictive value of preoperative serum sVEGF-C and sICAM-1 for the prognosis of patients with radical resection of gallbladder carcinoma.Methods Seventy-six patients with gallbladder cancer undergoing radical resection were selected.The serum sVEGF-C and sICAM-1 levels were detected by enzyme-linked immunosorbent assay.The prognosis of the patients was counted.Univariate analysis and multivariate Logistic regression analysis were used to analyze the factors affecting the prognosis of patients with gallbladder cancer after radical resection.ROC curve was used to analyze the efficacy of serum sVEGF-C and sICAM-1 levels in predicting the poor prognosis of patients with gallbladder cancer after radical resection.Results All patients were followed up for 1 year,and 38.16%(29/76)of them had poor prognosis.According to the prognosis,the patients were divided into good prognosis group and poor prognosis group.The preoperative serum sVEGF-C and sICAM-1 levels in the poor prognosis group were higher than those in the good prognosis group(P<0.05).There were significant differences in serum sVEGF-C and sICAM-1 levels among patients with different T stage,N stage,M stage and clinicopathological stage(P<0.05).T stage and N stage were the protective factors for the poor prognosis of patients with gallbladder cancer after radical resection(P<0.05),M stage,clinicopathological stage,serum sVEGF-C and sICAM-1 were the risk factors for the poor prognosis of patients with gallbladder cancer after radical resection(P<0.05).The AUC of serum sVEGF-C and sICAM-1 alone and in combination were 0.718,0.683 and 0.841,respectively.Conclusion The increase of preoperative serum sVEGF-C and sICAM-1 levels is related to the poor prognosis of patients with gallbladder cancer after radical resection.The combined detection of preoperative serum sVEGF-C and sICAM-1 has a high value in predicting the poor prognosis of patients with gallbladder cancer after radical resection.
作者
崔燕
杜晨阳
李康妹
郭彦杰
CUI Yan;DU Chenyang;LI Kangmei(The Third Affiliated Hospital of Xinxiang Medical College,Xinxiang,453000)
出处
《实用癌症杂志》
2025年第2期296-299,共4页
The Practical Journal of Cancer
