摘要
恶性肿瘤转移是导致患者预后不佳的关键因素,也是肿瘤治疗领域亟待攻克的棘手难题。代谢重编程作为调控肿瘤转移活性的关键环节,通过改变细胞内物质(如葡萄糖、氨基酸、脂质和核苷酸)代谢途径,影响肿瘤细胞的生长、侵袭及转移能力。尤其在肿瘤转移相关的多级联步骤中,代谢重编程都扮演着关键角色,可以对肿瘤组织原位解离、血行转移及远端定植等多个关键阶段发挥着至关重要的影响。恶性肿瘤细胞能够通过选择性地调整自身代谢状态,以适应不同转移微环境和定植部位生长条件,进而选择最有利的生长代谢策略。从中医学的整体观念出发,恶性肿瘤的转移一般都与全身代谢状态紧密相连。中药治疗恶性肿瘤的优势之一即为全身调节,中药以其多途径、多靶点、多成分的治疗特点,能够通过调节肿瘤上皮间质转化(EMT)、细胞外基质(ECM)的降解,肿瘤细胞锚定非依赖性生长及肿瘤微环境,有效控制恶性肿瘤的转移。该文深入探讨了代谢重编程对恶性肿瘤转移的潜在调控作用,并综述了中药调节代谢重编程抑制肿瘤转移的最新研究进展。同时,该文还梳理了中药及其生物活性成分在干预肿瘤转移过程中的关键靶点。此研究旨在为利用中药调节代谢重编程以治疗恶性肿瘤转移提供更具价值的依据和更为清晰的思路。
Malignant tumor metastasis is the key factor leading to poor prognosis of patients,and it is a difficult problem to be overcome in the field of tumor therapy.Metabolic reprogramming,as a key link in the regulation of tumor metastasis activity,affects the growth,invasion,and metastasis of tumor cells by changing the metabolic pathways of intracellular substances(such as glucose,amino acids,lipids,and nucleotides).In particular,metabolic reprogramming plays a key role in the multistage linked steps related to tumor metastasis and can play a crucial role in several key stages of tumor tissue dissociation in situ,hematogenous metastasis,and remote colonization.Malignant tumor cells can selectively adjust their own metabolic state to adapt to the growth conditions of different metastatic microenvironments and colonization sites and then choose the most favorable growth and metabolism strategy.According to the holistic concept of traditional Chinese medicine(TCM),the metastasis of malignant tumors is generally closely related to the metabolic state of the whole body.One of the advantages of TCM in the treatment of malignant tumors is systemic regulation.With its multi-pathway,multi-target,and multi-component therapeutic characteristics,TCM can effectively control the metastasis of malignant tumors by regulating the degradation of tumor epithelial mesenchymal transformation(EMT)and extracellular matrix(ECM),anchoring the independent growth of tumor cells and the tumor microenvironment.In this paper,the potential regulatory effects of metabolic reprogramming on the metastasis of malignant tumors were discussed,and the latest research progress of the regulation of metabolic reprogramming by TCM on tumor metastasis was reviewed.At the same time,the key targets of TCM and its bioactive components in the process of tumor metastasis intervention were reviewed.This study aims to provide a more valuable basis and clearer idea for the treatment of malignant tumor metastasis by regulating metabolic reprogramming with TCM.
作者
李贺生
李春婵
郭华慧
黄家晟
兰聪颖
陈鹏辉
黄仁发
LI Hesheng;LI Chunchan;GUO Huahui;HUANG Jiasheng;LAN Congying;CHEN Penghui;HUANG Renfa(Shenzhen Hospital,Guangzhou University of Chinese Medicine(Futian),Shenzhen 518034,China)
出处
《中国实验方剂学杂志》
北大核心
2025年第3期272-280,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81760805,81460682)
广东省自然科学基金资助课题(2020A1515010566,2020A151501572)
深圳市科技创新委员会课题项目(JCYJ20190809102413156)
深圳市福田区卫生与公益事业科研专项(FTWS2022014)。
关键词
代谢重编程
恶性肿瘤
转移
中医药
上皮间质转化
肿瘤微环境
生长代谢
metabolic reprogramming
malignant tumor
metastasis
traditional Chinese medicine
epithelial mesenchymal transformation(EMT)
tumor microenvironment
growth and metabolism
