摘要
目的:探讨血清生长激素(Growth hormone,GH)、胰岛素样生长因子-1(Insulin-like growth factors-1,IGF-1)与脓毒症患者临床预后的关系。方法:选取2020年4月至2023年8月期间于本院确诊并接受治疗的86例脓毒症患者纳入观察组。选取同期于本院进行体检的86例体检健康者纳入对照组。检测两组入院时的血清GH、IGF-1水平。统计观察组的预后情况,并根据患者预后情况将观察组进一步分为存活组和病死组。比较研究组的基线资料和入院时血清GH、IGF-1水平。采用COX风险模型检验血清GH、IGF-1与脓毒症患者生存结局的关系。结果:观察组入院时的血清GH、IGF-1均明显低于对照组(P<0.05)。86例脓毒症患者入院28 d内,病死率为30.23%(26/86)。病死组入院时的血清GH、IGF-1均明显低于存活组(P<0.05)。经COX生存回归分析结果显示,GH、IGF-1表达下调与脓毒症患者住院期间病死有关,可能是病死的危险因子(P<0.05)。结论:脓毒症患者入院时的血清GH、IGF-1呈低表达状态,二者异常低表达可能提示预后不良,是患者住院期间病死的危险因素。
Objective:To investigate the relationship between serum Growth hormone(GH),Insulin-like growth factor-1(IGF-1)and clinical prognosis in patients with sepsis.Methods:86 patients with sepsis diagnosed and treated in our hospital from April 2020 to August 2023 were included in the observation group.A total of 86 healthy subjects who underwent physical examination in our hospital during the same period were included in the control group.Serum GH and IGF-1 levels were detected in the two groups at admission.The prognosis of the observation group was analyzed,and the observation group was further divided into survival group and death group according to the prognosis of patients.The baseline data of the study group were compared with the serum GH and IGF-1 levels at admission.COX risk model was used to examine the relationship between serum GH,IGF-1 and survival outcome of sepsis patients.Results:The levels of serum GH and IGF-1 in the observation group were significantly lower than those in the control group(P<0.05).Among 86 patients with sepsis,the fatality rate was 30.23%(26/86)within 28 days.The levels of serum GH and IGF-1 in the death group were significantly lower than those in the survival group(P<0.05).COX survival regression analysis showed that decreased expression of GH and IGF-1 was associated with death during hospitalization in sepsis patients,and may be risk factors for death(P<0.05).Conclusion:The low expression of serum GH and IGF-1 in patients with sepsis at admission may indicate poor prognosis and may be a risk factor for death during hospitalization.
作者
宗珂璠
柴改会
尚钊源
Zong Ke-fan;Chai Gai-hui;Shang Zhao-yuan(Department of Nuclear Medicine,Xuchang Central Hospital,Xuchang 461000,Henan,China)
