摘要
目的 探究卡前列素氨丁三醇注射液联合卡贝缩宫素在剖宫产产后出血防治中的应用效果。方法 回顾性选取2021年1月至2022年12月郑州大学第三附属医院52例剖宫产产妇作为研究对象,按治疗方式不同将其分为对照组和观察组,各26例。对照组采用卡贝缩宫素治疗,观察组在此基础上采用卡前列素氨丁三醇注射液治疗。比较两组的凝血指标、产后出血发生率、产后24 h出血量、炎症应激指标及不良反应发生情况。结果 产后24 h,观察组的凝血酶时间(TT)、活化部分凝血活酶时间(APTT)短于对照组,纤维蛋白原(FIB)、D-二聚体(D-D)水平高于对照组,差异具有统计学意义(P<0.05)。观察组的产后出血发生率低于对照组,产后24 h出血量少于对照组,差异具有统计学意义(P<0.05)。产后48 h,观察组的C反应蛋白(CRP)、白细胞介素-6(IL-6)及降钙素原(PCT)水平低于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 卡前列素氨丁三醇注射液联合卡贝缩宫素在剖宫产产后出血防治中的效果显著,可改善凝血指标及炎症应激指标,降低产后出血发生率,减少产后出血量。
Objective To explore the application effect of carboprost tromethamine injection combined with carbetocin in the prevention and treatment of postpartum hemorrhage after cesarean section.Methods From January 2021 to December 2022,52 parturients with cesarean section in the Third Affiliated Hospital of Zhengzhou University were retrospectively selected as the research objects.According to different treatment methods,the parturients were divided into control group and observation group,with 26 cases in each group.The control group was treated with carbetocin,and the observation group was treated with carboprost tromethamine injection on this basis.The coagulation indexes,incidence of postpartum hemorrhage,at 24 h postpartum hemorrhage,inflammatory stress indexes and adverse reactions were compared between the two groups.Results At 24 h after delivery,the thrombin time(TT)and activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,the levels of fibrinogen(FIB)and D-dimer(D-D)were higher than those in the control group,and the differences were statistically significant(P<0.05).The incidence of postpartum hemorrhage in the observation group was lower than that in the control group,the amount of at 24 h postpartum hemorrhage was less than that in the control group,and the differences were statistically significant(P<0.05).At 48 h after delivery,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Carboprost tromethamine injection combined with carbetocin has a significant effect in the prevention and treatment of postpartum hemorrhage after cesarean section.It can improve coagulation indexes and inflammatory stress indexes,reduce the incidence of postpartum hemorrhage,and decrease the amount of postpartum hemorrhage.
作者
李鹤
LI He(Obstetrics Department,the Third Affiliated Hospital of Zhengzhou University/Maternal and Child Health Hospital of Henan Province,Zhengzhou 450052,China)
出处
《临床医学研究与实践》
2025年第4期139-142,共4页
Clinical Research and Practice
