摘要
目的探究消化内镜黏膜下剥离术治疗早期胃癌的效果。方法86例早期胃癌患者,根据治疗方法的不同分为参照组与研究组,每组43例。参照组接受消化内镜黏膜下切除术治疗,研究组接受消化内镜黏膜下剥离术治疗。比较两组手术治疗情况,肿瘤标记物、凝血功能、胃蛋白酶原、胃肠道动力激素指标水平。结果研究组患者的术中出血量(68.54±5.98)ml少于参照组的(87.69±6.35)ml,手术时间(66.29±4.98)min、术后排气时间(2.12±0.63)d、引流管拔除时间(4.87±0.63)d、自主下床活动时间(10.28±1.87)d短于参照组的(75.13±5.12)min、(3.21±0.54)d、(5.63±0.57)d、(12.36±2.16)d(P<0.05)。术后24 h,研究组患者的癌胚抗原(CEA)(19.21±4.12)μg/L、糖类抗原19-9(CA19-9)(20.46±5.27)U/ml低于参照组的(35.11±4.12)μg/L、(35.12±5.18)U/ml,活化部分凝血活酶时间(APTT)(38.96±3.45)s、凝血酶原时间(PT)(14.45±0.87)s、凝血酶时间(TT)(23.96±4.12)s长于参照组的(34.12±3.96)、(12.54±0.89)、(20.19±3.24)s(P<0.05)。术后1个月,研究组患者胃蛋白酶原Ⅰ(95.13±9.65)μg/L、胃动素(206.97±20.3)pg/ml显著高于参照组的(83.56±8.13)μg/L、(190.64±23.26)pg/ml,胃蛋白酶原Ⅱ(15.21±2.69)μg/L、血管活性肠肽(54.12±3.29)pg/ml显著低于参照组的(18.01±2.54)μg/L、(60.11±3.58)pg/ml(P<0.05)。结论与消化内镜黏膜下切除术相比,消化内镜黏膜下剥离术治疗早期胃癌的效果更佳,且预后更好。
Objective To explore the effect of digestive endoscopic submucosal dissection in the treatment of early gastric cancer.Methods According to different treatment methods,86 patients with early gastric cancer were divided into reference group and study group,with 43 cases in each group.The reference group received digestive endoscopic mucosal resection,and the study group received digestive endoscopic submucosal dissection.The surgical treatment,tumor markers,coagulation function,pepsinogen and gastrointestinal motility hormone indicators were compared between the two groups.Results The amount of intraoperative blood loss of(68.54±5.98)ml in the study group was less than(87.69±6.35)ml in the reference group;in the study group,the operation time was(66.29±4.98)min,the postoperative exhaust time was(2.12±0.63)d,the drainage tube removal time was(4.87±0.63)d,and the autonomous ambulation time was(10.28±1.87)d,which were shorter than(75.13±5.12)min,(3.21±0.54)d,(5.63±0.57)d,and(12.36±2.16)d in the reference group(P<0.05).At 24 h after surgery,the carcinoembryonic antigen(CEA)and the carbohydrate antigen 19-9(CA19-9)were(19.21±4.12)μg/L and(20.46±5.27)U/ml in the study group,which were lower than(35.11±4.12)μg/L and(35.12±5.18)U/ml in the reference group;the activated partial thromboplastin time(APTT)was(38.96±3.45)s,the prothrombin time(PT)was(14.45±0.87)s and the thromboplastin time(TT)was(23.96±4.12)s,which were longer than(34.12±3.96),(12.54±0.89)and(20.19±3.24)s in the reference group(P<0.05).At 1 month after surgery,the levels of pepsinogenⅠand motilin were(95.13±9.65)μg/L and(206.97±20.3)pg/ml in the study group,which were significantly higher than(83.56±8.13)μg/L and(190.64±23.26)pg/ml in the reference group;the pepsinogenⅡand vasoactive intestinal peptide were(15.21±2.69)μg/L and(54.12±3.29)pg/ml in the study group,which were significantly lower than(18.01±2.54)μg/L and(60.11±3.58)pg/ml in the reference group(P<0.05).Conclusion Compared with digestive endoscopic mucosal resection,digestive endoscopic submucosal dissection is more effective in treating early gastric cancer and has a better prognosis.
作者
苗兰英
杨卓
MIAO Lan-ying;YANG Zhuo(Northern Theater Command General Hospital,Shenyang 110016,China)
出处
《中国实用医药》
2025年第2期38-41,共4页
China Practical Medicine
关键词
消化内镜黏膜下剥离术
早期胃癌
疗效
不良反应
Digestive endoscopic submucosal dissection
Early gastric cancer
Curative effect
Adverse reactions
