摘要
炎症性肠病(IBD)是一种病因不明的慢性非特异性胃肠道疾病,全球发病率日益升高。传统观点认为白细胞介素-13(IL-13)仅发挥抗炎作用,但近年研究发现IL-13可通过破坏肠上皮屏障以及IL-13受体α2(IL-13Rα2)介导的通路形成肠纤维化和肠瘘,发挥促炎作用。本文就IL-13在IBD中作用的研究进展作一综述,旨在为优化IBD的治疗提供帮助。
Inflammatory bowel disease(IBD)is a chronic non-specific gastrointestinal disorder of unknown etiology and its global incidence is increasing.The traditional view holds that interleukin-13(IL-13)only plays an anti-inflammatory role,but recent studies have demonstrated that IL-13 also plays a pro-inflammatory role by disrupting the intestinal epithelial barrier and forming intestinal fibrosis and intestinal fistula through the IL-13 receptor alpha 2(IL-13Rα2)-mediated pathway.This article reviewed the progress of research on the role of IL-13 in IBD,aiming to provide a reference for optimizing the treatment of IBD.
作者
鲍文扬
陈可
范梦磊
黄晓慧
王如怡
石千千
王小云
BAO Wenyang;CHEN Ke;FAN Menglei;HUANG Xiaohui;WANG Ruyi;SHI Qianqian;WANG Xiaoyun(Department of Gastroenterology,Jiangnan University Affiliated Central Hospital(Wuxi Second People′s Hospital),Wuxi,Jiangsu Province,214002;Wuxi Clinical College of Nantong University,Wuxi,Jiangsu Province)
出处
《胃肠病学》
2024年第6期376-381,共6页
Chinese Journal of Gastroenterology
基金
无锡市医学创新团队建设(胃肠病学)(CXTD2021020)
无锡市“双百”中青年医疗卫生拔尖人才培养计划(BJ2020024)。
关键词
白细胞介素13
炎症性肠病
肠纤维化
Interleukin-13
Inflammatory Bowel Disease
Intestinal Fibrosis
