摘要
原发性干燥综合征(PSS)是一种慢性自身免疫性疾病,病因复杂,发病机制尚不明确,可以影响全身各个器官、系统,主要影响人体的外分泌腺。PSS持续时间长,无法治愈,因此患者常合并不同程度的焦虑。目前,PSS合并焦虑障碍的发病机制仍不清楚,可能与疾病本身、细胞因子紊乱、中枢神经系统受损以及社会心理因素等有关。因此,寻找PSS合并焦虑障碍发病相关的细胞因子及可能的代谢途径并阐明其介导焦虑发病的可能机制是PSS的研究重点。
Primary Sjogren's syndrome(PSS)is a chronic autoimmune disease with complex etiology and unclear pathogenesis.It can affect various organs and systems throughout the body,mainly affecting the exocrine glands of the human body.PSS has a long duration and cannot be cured,so the patients often have varying degrees of anxiety.At present,the pathogenesis of PSS combined with anxiety disorders is still unclear,which may be related to the disease itself,cytokine disorders,central nervous system damage,and social and psychological factors.Therefore,the focus of PSS research is to identify the cytokines and possible metabolic pathways associated with the development of PSS combined with anxiety disorders and elucidate their possible mechanisms in mediating the onset of anxiety.
作者
赵双
邹晋梅
ZHAO Shuang;ZOU Jinmei(Department of Clinical Medicine,Chengdu Medical College,Chengdu 610500,China;Department of Rheumatology and Immunology,Mianyang Central Hospital,Mianyang 621000,China)
出处
《医学综述》
2025年第5期599-603,共5页
Medical Recapitulate
基金
绵阳市中心医院孵化课题(2022FH006)。
关键词
原发性干燥综合征
焦虑障碍
发病机制
Primary Sjogren's syndrome
Anxiety disorders
Pathogenesis
